Carrillo-Martin Ismael, Gonzalez-Estrada Alexei, Funni Shealeigh A, Jeffery Molly M, Inselman Jonathan W, Campbell Ronna L
Division of Pulmonary, Allergy and Sleep Medicine, Department of Medicine, Mayo Clinic, Jacksonville, Fla.
Division of Pulmonary, Allergy and Sleep Medicine, Department of Medicine, Mayo Clinic, Jacksonville, Fla.
J Allergy Clin Immunol Pract. 2020 Oct;8(9):2983-2988. doi: 10.1016/j.jaip.2020.05.056. Epub 2020 Jun 15.
Allergic reactions, angioedema, and anaphylaxis are commonly treated in the emergency department (ED). Contemporary evidence suggests that these conditions may be increasing in the United States.
To evaluate the contemporary epidemiology and trends of ED visits for allergic reactions, angioedema, and anaphylaxis in the United States from 2007 to 2015.
Using de-identified data from the National Hospital Ambulatory Medical Care Survey from 2007 to 2015, we identified cases of acute allergic reactions, angioedema, and anaphylaxis through International Classification of Diseases, 9th Revision, Clinical Modification codes and conducted a retrospective analysis of rates and trends of these allergy-related ED visits.
There was a 14% overall increase in allergy-related ED visits between 2007 and 2015. Approximately 10 million ED visits in this time frame were associated with allergy-related conditions accounting for 0.85% (95% CI, 0.79-0.90) of all ED visits in the United States. Almost 3% of allergy-related ED visits were coded as anaphylaxis of which 46.1% (95% CI, 27.5-64.6) received epinephrine. Patients younger than 10 years had a higher relative risk (1.3; 95% CI, 1.0-1.6; P = .027) of allergy-related ED visits per 1000 ED visits than patients 65 years and older, and women also had a higher relative risk (1.4; 95% CI, 1.2-1.5; P < .001) than men.
Allergy-related ED visits increased 14% from 2007 to 2015, with the highest relative risk occurring in patients younger than 10 years. These data provide further evidence of increasing allergic conditions in the United States.
过敏反应、血管性水肿和过敏症通常在急诊科（ED）进行治疗。当代证据表明，在美国这些病症可能正在增加。
评估2007年至2015年美国急诊科因过敏反应、血管性水肿和过敏症就诊的当代流行病学情况及趋势。
利用2007年至2015年美国国家医院门诊医疗调查中去除身份标识的数据，我们通过国际疾病分类第九版临床修订本编码识别出急性过敏反应、血管性水肿和过敏症病例，并对这些与过敏相关的急诊科就诊率及趋势进行回顾性分析。
2007年至2015年期间，与过敏相关的急诊科就诊人次总体增加了14%。在此期间，约有1000万次急诊科就诊与过敏相关病症有关，占美国所有急诊科就诊人次的0.85%（95%置信区间，0.79 - 0.90）。几乎3%的与过敏相关的急诊科就诊被编码为过敏症，其中46.1%（95%置信区间，27.5 - 64.6）接受了肾上腺素治疗。每1000次急诊科就诊中，10岁以下患者发生与过敏相关的急诊科就诊的相对风险（1.3；95%置信区间，1.0 - 1.6；P = 0.027）高于65岁及以上患者，女性的相对风险（1.4；95%置信区间，1.2 - 1.5；P < 0.001）也高于男性。
2007年至2015年，与过敏相关的急诊科就诊人次增加了14%，10岁以下患者的相对风险最高。这些数据为美国过敏病症增加提供了进一步证据。
