Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, PR China; College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China.
College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China.
Int J Biol Macromol. 2020 Oct 15;161:1140-1148. doi: 10.1016/j.ijbiomac.2020.06.094. Epub 2020 Jun 15.
Carboxymethyl cellulose (CMC)/pPoly-N-isopropylacrylamide (PNIPAM) hydrogels were prepared using nanoclay as physical cross-linker by UV irradiation. PNIPAM/CMC hydrogels exhibit 3D network structures with high porosity. PNIPAM/CMC hydrogels exhibit not only high water absorption capacity, but also temperature, pH and salt mutiple-responsive swelling performance. Besides, they exhibit reversible swelling behavior in alternate de-ionized water and NaCl solution. Moreover, the fabricated PNIPAM/CMC hydrogels display great compression mechanical property. Then, tetracycline hydrochloride (TCH) was loaded into the PNIPAM/CMC hydrogels to endow their antibacterial ability. TCH loaded PNIPAM/CMC hydrogels exhibit excellent antibacterial activity against E. coli and B. subtilis and good biocompatibility. Thus, the PNIPAM/CMC composite hydrogels with triple stimuli-responsive swelling performances reported herein have great potentials in many biomedical applications.
羧甲基纤维素（CMC）/聚-N-异丙基丙烯酰胺（PNIPAM）水凝胶是通过紫外光辐照使用纳米粘土作为物理交联剂制备的。PNIPAM/CMC 水凝胶具有高孔隙率的 3D 网络结构。PNIPAM/CMC 水凝胶不仅具有高吸水性，而且还具有温度、pH 值和盐多重响应的溶胀性能。此外，它们在去离子水和 NaCl 溶液之间表现出可逆的溶胀行为。此外，所制备的 PNIPAM/CMC 水凝胶具有良好的压缩力学性能。然后，盐酸四环素（TCH）被载入 PNIPAM/CMC 水凝胶中，赋予其抗菌能力。负载 TCH 的 PNIPAM/CMC 水凝胶对大肠杆菌和枯草芽孢杆菌表现出优异的抗菌活性和良好的生物相容性。因此，本文报道的具有三重刺激响应溶胀性能的 PNIPAM/CMC 复合水凝胶在许多生物医学应用中具有巨大的潜力。
