Bao Yunhui, He Jian, Song Ke, Guo Jie, Zhou Xianwu, Liu Shima
Key Laboratory of Hunan Forest Products and Chemical Industry Engineering, Jishou University, Zhangjiajie 427000, China.
College of Chemistry and Chemical Engineering, Jishou University, Jishou 416000, China.
Polymers (Basel). 2022 Feb 16;14(4):769. doi: 10.3390/polym14040769.
Pathogens, especially drug-resistant pathogens caused by the abuse of antibiotics, have become a major threat to human health and public health safety. The exploitation and application of new antibacterial agents is extremely urgent. As a natural biopolymer, cellulose has recently attracted much attention due to its excellent hydrophilicity, economy, biocompatibility, and biodegradability. In particular, the preparation of cellulose-based hydrogels with excellent structure and properties from cellulose and its derivatives has received increasing attention thanks to the existence of abundant hydrophilic functional groups (such as hydroxyl, carboxy, and aldehyde groups) within cellulose and its derivatives. The cellulose-based hydrogels have broad application prospects in antibacterial-related biomedical fields. The latest advances of preparation and antibacterial application of cellulose-based hydrogels has been reviewed, with a focus on the antibacterial applications of composite hydrogels formed from cellulose and metal nanoparticles; metal oxide nanoparticles; antibiotics; polymers; and plant extracts. In addition, the antibacterial mechanism and antibacterial characteristics of different cellulose-based antibacterial hydrogels were also summarized. Furthermore, the prospects and challenges of cellulose-based antibacterial hydrogels in biomedical applications were also discussed.
病原体，尤其是抗生素滥用导致的耐药病原体，已成为对人类健康和公共卫生安全的重大威胁。新型抗菌剂的开发和应用迫在眉睫。纤维素作为一种天然生物聚合物，由于其优异的亲水性、经济性、生物相容性和生物降解性，近年来备受关注。特别是，纤维素及其衍生物具有丰富的亲水性官能团（如羟基、羧基和醛基），由此制备出具有优异结构和性能的纤维素基水凝胶受到越来越多的关注。纤维素基水凝胶在抗菌相关生物医学领域具有广阔的应用前景。本文综述了纤维素基水凝胶制备及其抗菌应用的最新进展，重点介绍了由纤维素与金属纳米颗粒、金属氧化物纳米颗粒、抗生素、聚合物和植物提取物形成的复合水凝胶的抗菌应用。此外，还总结了不同纤维素基抗菌水凝胶的抗菌机制和抗菌特性。此外，还讨论了纤维素基抗菌水凝胶在生物医学应用中的前景和挑战。
