Gibb W R
Department of Neuropathology, National Hospitals for Nervous Diseases, Maida Vale.
Br J Psychiatry. 1988 Aug;153:254-5. doi: 10.1192/bjp.153.2.254.
A case of probable neuroleptic malignant syndrome (NMS) complicating L-dopa withdrawal in striatonigral degeneration is described. This case suggests that the hyperthermia of NMS is due to peripheral heat production associated with severe muscular rigidity secondary to withdrawal of striatal dopamine drive, rather than being centrally mediated by the hypothalamus, which is not involved in striatonigral degeneration.
本文描述了一例纹状体黑质变性患者在停用左旋多巴时并发可能的抗精神病药恶性综合征（NMS）的病例。该病例提示，NMS的高热是由于纹状体多巴胺驱动撤除继发严重肌肉强直所导致的外周产热，而非由下丘脑进行中枢介导，而下丘脑并不参与纹状体黑质变性。
