Kan A E
Pathology. 1978 Jan;10(1):45-52. doi: 10.3109/00313027809063478.
Striatonigral degeneration is a relatively uncommon form of parkinsonism. It is clinically characterized by greater debility and a relatively rapid course, often with other superimposed extrapyramidal signs and a poor response to L-dopa. Pathologically it si a multi-system degeneration of the central nervous system, dominated by atrophy of the neostriatum with striking putaminal pigmentation. The clinical and pathological features of this condition are illustrated with a case report and the entity as a nosologic problem is discussed in the light of a review of the literature. The pathogenesis of this condition and its position among the degenerative disorders of the nervous system remain unelucidated.
纹状体黑质变性是一种相对不常见的帕金森综合征形式。其临床特征为衰弱更明显且病程相对较快，常伴有其他叠加的锥体外系体征，对左旋多巴反应不佳。病理上，它是中枢神经系统的多系统变性，以新纹状体萎缩为主，伴有显著的壳核色素沉着。通过一例病例报告阐述了这种疾病的临床和病理特征，并根据文献综述讨论了该疾病作为一个分类学问题的情况。这种疾病的发病机制及其在神经系统退行性疾病中的地位仍未阐明。
