Drug modulation by nuclear condensates.
作者信息
Viny Aaron D, Levine Ross L
机构信息
Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
出版信息
Science. 2020 Jun 19;368(6497):1314-1315. doi: 10.1126/science.abc5318.
Abstract
摘要
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本文引用的文献
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Evaluating phase separation in live cells: diagnosis, caveats, and functional consequences.评估活细胞中的相分离：诊断、注意事项和功能后果。
Genes Dev. 2019 Dec 1;33(23-24):1619-1634. doi: 10.1101/gad.331520.119. Epub 2019 Oct 8.
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Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains.转录因子通过其激活结构域的相分离能力激活基因。
Cell. 2018 Dec 13;175(7):1842-1855.e16. doi: 10.1016/j.cell.2018.10.042. Epub 2018 Nov 15.
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Coexisting Liquid Phases Underlie Nucleolar Subcompartments.共存液相构成核仁亚区室的基础。
Cell. 2016 Jun 16;165(7):1686-1697. doi: 10.1016/j.cell.2016.04.047. Epub 2016 May 19.
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Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes.核仁的液态样活性决定了爪蟾卵母细胞中核仁的大小和形状。
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