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婴儿感染 SARS-CoV-2 导致严重肺部疾病,用瑞德西韦治疗。

Infant With SARS-CoV-2 Infection Causing Severe Lung Disease Treated With Remdesivir.

机构信息

Great Ormond Street Hospital for Children National Health Service Foundation Trust, London, United Kingdom.

Division of Surgery, Adelaide Medical School, The University of Adelaide, Adelaide, South Australia.

出版信息

Pediatrics. 2020 Sep;146(3). doi: 10.1542/peds.2020-1701. Epub 2020 Jun 18.

Abstract

We describe an ex-premature infant presenting with severe acute respiratory syndrome coronavirus 2 infection in the fifth week of life. In current reports, researchers indicate that acute symptomatic severe acute respiratory syndrome coronavirus 2 infection is relatively rare and much less severe than in adults. This case highlights that infection can be associated with life-threatening pulmonary disease in young infants and that infection can follow a similar disease course to that described in adults. We provide first data on the use of the novel antiviral remdesivir in a young child and an innovative approach to expedited approval from a multidisciplinary clinical team and bioethics committee for compassionate access to the drug.

摘要

我们描述了一例在第五周生命时患有严重急性呼吸综合征冠状病毒 2 感染的早产儿。在目前的报告中,研究人员表明,急性有症状的严重急性呼吸综合征冠状病毒 2 感染相对较少见,且比成人轻得多。本病例突出表明,感染可能与年幼婴儿的危及生命的肺部疾病相关,并且感染可能遵循与在成人中描述的相似的疾病过程。我们提供了首例在幼儿中使用新型抗病毒药物瑞德西韦的数据,并介绍了多学科临床团队和生物伦理委员会为同情使用该药物而加速批准的创新方法。

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