Department of Veterinary Physiology, Faculty of Veterinary Science, Chulalongkorn University, 39 Henri-Dunant Road, Wangmai, Pathumwan, Bangkok, Thailand.
Department of Veterinary Surgery, Faculty of Veterinary Science, Chulalongkorn University, 39 Henri-Dunant Road, Wangmai, Pathumwan, Bangkok, Thailand.
J Vet Med Sci. 2020 Aug 19;82(8):1104-1112. doi: 10.1292/jvms.19-0496. Epub 2020 Jun 18.
Chronic kidney disease (CKD) is a common renal disease in dogs and cats. Renal fibrosis is a main pathologic process leading of CKD progression. Renal biopsy is the gold standard for renal fibrosis assessment. However, it is not routinely performed in clinic due to its invasiveness. Therefore, the aim of this study was to evaluate the use of ultrasonographic strain elastography (SE), which is a non-invasive method for renal tissue stiffness determination and its association with renal function. Renal strain ratios and renal function were evaluated in 13 CKD dogs (CKDD), 38 healthy dogs (HD), 17 CKD cats (CKDC) and 26 healthy cats (HC). There were significantly lower renal cortical strain ratios than medullary strain ratios in all groups (HD; P<0.01, HC; P<0.01, CKDD and CKDC; P<0.05) and significantly lower cortical and medullary strain ratios in both CKDD and CKDC than in healthy control animals of both species (P<0.0001). In dogs, the renal cortical and medullary strain ratios significantly negatively correlated with plasma creatinine (P<0.05), blood urea nitrogen (BUN; P<0.05; P<0.01, respectively), and symmetric dimethylarginine (SDMA; P<0.01). In cats, similar correlations were found for plasma creatinine (P<0.001), BUN (P<0.05; P<0.001, respectively) and SDMA (P<0.05). SE might be a promising imaging diagnostic tool for renal-elasticity evaluation, also correlating with renal functional impairment in canine and feline CKD.
慢性肾脏病（CKD）是犬猫常见的肾脏疾病。肾纤维化是导致 CKD 进展的主要病理过程。肾脏活组织检查是评估肾纤维化的金标准。然而，由于其侵袭性，在临床上并未常规进行。因此，本研究旨在评估超声应变弹性成像（SE）的应用，SE 是一种用于确定肾脏组织硬度的非侵入性方法及其与肾功能的关系。在 13 只 CKD 犬（CKDD）、38 只健康犬（HD）、17 只 CKD 猫（CKDC）和 26 只健康猫（HC）中评估了肾脏应变比和肾功能。所有组的肾皮质应变比均明显低于髓质应变比（HD：P<0.01，HC：P<0.01，CKDD 和 CKDC：P<0.05），CKDD 和 CKDC 的皮质和髓质应变比均明显低于两种物种的健康对照动物（P<0.0001）。在犬中，肾皮质和髓质应变比与血浆肌酐（P<0.05）、血尿素氮（BUN；P<0.05；P<0.01）和对称二甲基精氨酸（SDMA；P<0.01）呈显著负相关。在猫中，也发现了与血浆肌酐（P<0.001）、BUN（P<0.05；P<0.001）和 SDMA（P<0.05）的相似相关性。SE 可能是一种很有前途的肾脏弹性成像诊断工具，也与犬和猫 CKD 的肾功能损害相关。
