Shahidi Mohsen, Hashemi Sayedeh Rozhin, Fattahi Nima, Roshani Daem, Vahedi Siamak, Sharifi Pezhman, Moradveisi Borhan
Department of Cardiology, Besat Hospital.
Faculty of Medicine.
J Pediatr Hematol Oncol. 2020 Aug;42(6):386-390. doi: 10.1097/MPH.0000000000001850.
Heart failure, fatal arrhythmias, and cardiac dilatation because of anemia are common causes of β-thalassemia major-related deaths. The aim of this study was to determine the effect of L-carnitine on echocardiographic changes in β-thalassemia major and intermedia patients in Besat Hospital in Sanandaj, Iran.
In a randomized clinical trial, 60 β-thalassemia patients who were eligible for L-carnitine administration were randomly divided into 2 placebo and study drug groups. The duration of the study was 6 months. Using echocardiography and blood tests, cardiac parameters including left ventricular dilatation, left ventricular hypertrophy, and a number of cardiac blood indices were examined before and after the intervention. The data were analyzed using SPSS V.23 software, χ, and covariance statistical tests.
There was no significant difference between the 2 groups in terms of age and sex. Patients treated with L-carnitine have a reduced rate of left ventricular dilatation, left ventricular hypertrophy, and systolic blood pressure compared with controls (P<0.05). Cardiac output increased from 43.5 to 56.5 (P=0.002).
The results of this study showed that the drug has a positive effect on the improvement of cardiac indices in β-thalassemia patients. Therefore, we suggest that further studies with more samples and other diagnostic modalities of the drug's effect be investigated.
心力衰竭、致命性心律失常以及因贫血导致的心脏扩张是重型β地中海贫血相关死亡的常见原因。本研究的目的是确定左旋肉碱对伊朗萨南达杰贝萨特医院重型和中间型β地中海贫血患者超声心动图变化的影响。
在一项随机临床试验中，60名符合左旋肉碱给药条件的β地中海贫血患者被随机分为2个安慰剂组和研究药物组。研究持续时间为6个月。使用超声心动图和血液检测，在干预前后检查包括左心室扩张、左心室肥厚以及一些心脏血液指标在内的心脏参数。数据使用SPSS V.23软件、χ检验和协方差统计检验进行分析。
两组在年龄和性别方面无显著差异。与对照组相比，接受左旋肉碱治疗的患者左心室扩张、左心室肥厚和收缩压的发生率降低（P<0.05）。心输出量从43.5增加到56.5（P=0.002）。
本研究结果表明该药物对改善β地中海贫血患者的心脏指标有积极作用。因此，我们建议对该药物作用进行更多样本和其他诊断方式的进一步研究。
