Guzman Luis, Nerio Luz S, Venturini Whitney, Macias Julyleth P J, Donoso Wendy, Forero-Doria Oscar
Universidad de Talca, Departamento de Bioquímica Clínica e Inmunohematología, Facultad de Ciencias de la Salud, Avenida Lircay, s/n, Casilla 747-721, Talca, Chile.
Universidad de la Amazonia, Programa de Química, Calle 17 Diagonal 17 Carrera 3F, Florencia, Colombia.
An Acad Bras Cienc. 2020 Jun 12;92(2):e20190615. doi: 10.1590/0001-3765202020190615. eCollection 2020.
Hedychium coronarium J. Koening, belonging to Zingiberaceae family, is a perennial herb with fleshly aromatic rhizomes. There are no information about the antiplatelet properties of essential oils (EOs) from rhizomes (HCR) and leaves (HCL) of this herb, additionally, there are reports about the antibacterial activity of the Zingiberaceae species, however, no studies have been carried out in the Colombian Amazon Region. The EOs were characterized by GC-MS, the antiaggregant activity was assessed by ADP and Collagen as platelet agonist and the antibacterial activity against E. faecalis and S. aureus were evidenced by the determination of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). A high content of oxygenated monoterpenes were found in HCL essential oil (EO) and 20 compounds were identified in HCR EO. The HCL EO showed antiaggregant activity when collagen was used and HCR EO showed a concentration-dependent activity against ADP and collagen, meanwhile only the HCR EO showed antibacterial activity against E. faecalis and S. aureus.
姜花（Hedychium coronarium J. Koening）属于姜科，是一种具有肉质芳香根茎的多年生草本植物。关于该植物根茎（HCR）和叶片（HCL）的精油（EOs）的抗血小板特性尚无相关信息，此外，有关于姜科植物抗菌活性的报道，但在哥伦比亚亚马逊地区尚未开展相关研究。通过气相色谱 - 质谱联用（GC-MS）对精油进行了表征，以二磷酸腺苷（ADP）和胶原蛋白作为血小板激动剂评估抗聚集活性，并通过测定最低抑菌浓度（MIC）和最低杀菌浓度（MBC）来证明对粪肠球菌和金黄色葡萄球菌的抗菌活性。在HCL精油（EO）中发现了高含量的氧化单萜，在HCR EO中鉴定出20种化合物。当使用胶原蛋白时，HCL EO表现出抗聚集活性，HCR EO对ADP和胶原蛋白表现出浓度依赖性活性，同时只有HCR EO对粪肠球菌和金黄色葡萄球菌表现出抗菌活性。
