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免疫检查点抑制剂治疗转移性黑色素瘤患者的生精功能损害与免疫检查点抑制剂的相关性。

Association of Impaired Spermatogenesis With the Use of Immune Checkpoint Inhibitors in Patients With Metastatic Melanoma.

机构信息

Scott Department of Urology, Baylor College of Medicine, Houston, Texas.

Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio.

出版信息

JAMA Oncol. 2020 Aug 1;6(8):1297-1299. doi: 10.1001/jamaoncol.2020.1641.

DOI:10.1001/jamaoncol.2020.1641
PMID:32556068
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7303895/
Abstract

This cohort study examines the potential association of the use of immune checkpoint inhibitors with testicular histopathologic conditions.

摘要

本队列研究探讨了免疫检查点抑制剂的使用与睾丸组织病理状况之间的潜在关联。

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本文引用的文献

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Effect of a formal oncofertility program on fertility preservation rates-first year experience.一项正式的肿瘤生育力保存计划对生育力保存率的影响——首年经验
Transl Androl Urol. 2018 Jul;7(Suppl 3):S271-S275. doi: 10.21037/tau.2018.04.24.
2
Endocrine, Sexual Function, and Infertility Side Effects of Immune Checkpoint Inhibitor Therapy for Genitourinary Cancers.免疫检查点抑制剂治疗泌尿生殖系统癌症的内分泌、性功能及不孕副作用
Curr Urol Rep. 2018 Jul 3;19(9):68. doi: 10.1007/s11934-018-0819-7.
3
Fertility Preservation in Patients With Cancer: ASCO Clinical Practice Guideline Update.癌症患者的生育力保存：ASCO 临床实践指南更新。
J Clin Oncol. 2018 Jul 1;36(19):1994-2001. doi: 10.1200/JCO.2018.78.1914. Epub 2018 Apr 5.
4
Prevalence and Predictors of Sperm Banking in Adolescents Newly Diagnosed With Cancer: Examination of Adolescent, Parent, and Provider Factors Influencing Fertility Preservation Outcomes.新诊断为癌症的青少年精子库的患病率及预测因素：对影响生育力保存结果的青少年、父母及医疗服务提供者因素的研究。
J Clin Oncol. 2017 Dec 1;35(34):3830-3836. doi: 10.1200/JCO.2016.70.4767. Epub 2017 Oct 4.
5
Combined nivolumab and ipilimumab versus ipilimumab alone in patients with advanced melanoma: 2-year overall survival outcomes in a multicentre, randomised, controlled, phase 2 trial.纳武利尤单抗与伊匹木单抗联合用药对比伊匹木单抗单药治疗晚期黑色素瘤患者：一项多中心、随机、对照、2期试验的2年总生存结果
Lancet Oncol. 2016 Nov;17(11):1558-1568. doi: 10.1016/S1470-2045(16)30366-7. Epub 2016 Sep 9.
6
Testicular biopsy score count--a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males.睾丸活检评分计数——一种记录人类睾丸生精功能的方法：335例性腺功能减退男性的正常值及结果
Hormones. 1970;1(1):2-25. doi: 10.1159/000178170.