Engrailed Homeobox 1 和细胞角蛋白 19 是汗管癌的独立诊断标志物，可将其与鳞状细胞癌区分开来。
Engrailed Homeobox 1 and Cytokeratin 19 Are Independent Diagnostic Markers of Eccrine Porocarcinoma and Distinguish It From Squamous Cell Carcinoma.
机构信息
Division of Surgical Pathology, University Hospital, Tokyo, Japan.
Department of Diagnostic Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
出版信息
Am J Clin Pathol. 2020 Sep 8;154(4):499-509. doi: 10.1093/ajcp/aqaa066.
OBJECTIVES
The diagnostic utility of En1 in the histopathologic differentiation of eccrine porocarcinoma (EPC) from invasive squamous cell carcinoma (SCC) was investigated.
METHODS
Expression of En1 and CK19 in 16 cases of EPC was immunohistochemically examined and compared with that in 32 cases of SCC.
RESULTS
In all 16 EPCs, En1 was expressed in 3% to 100% of tumor cells. In 20 of the 32 SCCs, En1 was expressed in 3% to 90% of tumor cells. A total of 13 of the 16 EPCs and five of the 32 SCCs were judged as En1 positive, with a cutoff value of 25%. In addition, 11 of the 16 EPCs and four of the 32 SCCs were CK19 positive. The frequencies of En1- and CK19-positive cases were significantly higher in EPCs than in SCCs. In a logistic regression analysis for predicting EPC, En1 and CK19 were independent markers. When expression patterns of En1 and CK19 were combined, none of the 32 SCCs was both positive. In contrast, 15 of the 16 EPCs were positive for either En1 or CK19.
CONCLUSIONS
A combination of En1 and CK19 expression can improve the accuracy of histologic diagnosis of EPC.
目的
研究 En1 在汗管癌（EPC）与侵袭性鳞状细胞癌（SCC）的组织病理学鉴别诊断中的应用价值。
方法
采用免疫组织化学方法检测 16 例 EPC 和 32 例 SCC 中 En1 和 CK19 的表达情况，并进行比较。
结果
在 16 例 EPC 中，En1 在 3%至 100%的肿瘤细胞中表达。在 32 例 SCC 中，En1 在 3%至 90%的肿瘤细胞中表达。在 16 例 EPC 中，有 13 例和 32 例 SCC 中有 5 例 En1 阳性，截断值为 25%。此外，11 例 EPC 和 4 例 SCC 为 CK19 阳性。EPC 中 En1 和 CK19 阳性病例的频率明显高于 SCC。在预测 EPC 的逻辑回归分析中，En1 和 CK19 均为独立标志物。当 En1 和 CK19 的表达模式相结合时，32 例 SCC 均为阴性。相比之下，16 例 EPC 中有 15 例 En1 或 CK19 阳性。
结论
En1 和 CK19 表达的联合可以提高 EPC 组织学诊断的准确性。
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