前列腺癌生物学中的血清睾酮与肥胖：呼吁促进老年男性健康 - Suppr

Serum testosterone and obesity in prostate cancer biology: a call for health promotion in the ageing male.

作者信息

Tafuri Alessandro, Porcaro Antonio B, Shakir Aliasger, Migliorini Filippo, Verratti Vittore, Brunelli Matteo, Cerruto Maria Angela, Antonelli Alessandro

机构信息

Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata Verona, Piazzale Stefani 1, 37126, Verona, Italy.

Department of Neuroscience, Imaging and Clinical Science, Physiology and Physiopathology Division, "G. D'Annunzio" University, Chieti, Italy.

出版信息

Aging Clin Exp Res. 2021 May;33(5):1399-1401. doi: 10.1007/s40520-020-01625-w. Epub 2020 Jun 17.

DOI:10.1007/s40520-020-01625-w

PMID:32557331

Abstract

摘要

相似文献

Serum testosterone and obesity in prostate cancer biology: a call for health promotion in the ageing male.前列腺癌生物学中的血清睾酮与肥胖：呼吁促进老年男性健康

Aging Clin Exp Res. 2021 May;33(5):1399-1401. doi: 10.1007/s40520-020-01625-w. Epub 2020 Jun 17.

Low Serum Testosterone But Not Obesity Predicts High Gleason Score at Biopsy Diagnosed as Prostate Cancer in Patients with Serum PSA Lower than 20 ng/ml.血清前列腺特异抗原（PSA）低于20 ng/ml的前列腺癌患者活检时，低血清睾酮而非肥胖可预测高Gleason评分。

Anticancer Res. 2015 Nov;35(11):6137-45.

High serum dihydrotestosterone examined by ultrasensitive LC-MS/MS as a predictor of benign prostatic hyperplasia or Gleason score 6 cancer in men with prostate-specific antigen levels of 3-10 ng/mL.采用超灵敏液相色谱-串联质谱法检测的高血清双氢睾酮作为前列腺特异性抗原水平为3-10 ng/mL男性良性前列腺增生或Gleason评分6分癌症的预测指标。

Andrology. 2017 Mar;5(2):262-267. doi: 10.1111/andr.12294. Epub 2016 Nov 3.

Corpulence is the crucial factor: association of testosterone and/or obesity with prostate cancer stage.肥胖是关键因素：睾酮和/或肥胖与前列腺癌分期的关联。

Int J Urol. 2014 Oct;21(10):980-6. doi: 10.1111/iju.12494. Epub 2014 May 27.

Obesity, serum prostate specific antigen and prostate size: implications for prostate cancer detection.肥胖、血清前列腺特异性抗原与前列腺大小：对前列腺癌检测的影响

J Urol. 2006 Feb;175(2):500-4; discussion 504. doi: 10.1016/S0022-5347(05)00162-X.

Testosterone replacement therapy and prostate cancer: a word of caution.睾酮替代疗法与前列腺癌：一则警示

Curr Urol Rep. 2007 May;8(3):185-9. doi: 10.1007/s11934-007-0004-x.

Serum testosterone as a biomarker for second prostatic biopsy in men with negative first biopsy for prostatic cancer and PSA>4ng/mL, or with PIN biopsy result.血清睾酮作为前列腺癌首次活检阴性且前列腺特异性抗原（PSA）>4 ng/mL 或前列腺上皮内瘤变（PIN）活检结果男性患者第二次前列腺活检的生物标志物。

Int Braz J Urol. 2016 Sep-Oct;42(5):925-931. doi: 10.1590/S1677-5538.IBJU.2015.0167.

[Quantitative changes of testosterone and prostate-specific antigen at low and high densities of PSA in men with prostate cancer].

Georgian Med News. 2007 Feb(143):67-9.

Analysis of relations between serum levels of epitestosterone, estradiol, testosterone, IGF-1 and prostatic specific antigen in men with benign prostatic hyperplasia and carcinoma of the prostate.良性前列腺增生和前列腺癌男性血清表睾酮、雌二醇、睾酮、胰岛素样生长因子-1与前列腺特异性抗原水平之间的关系分析。

Physiol Res. 2000;49 Suppl 1:S113-8.

The ratio of serum testosterone-to-prostate specific antigen predicts prostate cancer in hypogonadal men.血清睾酮与前列腺特异性抗原的比值可预测性腺功能减退男性患前列腺癌的风险。

J Urol. 2008 May;179(5):1741-4. doi: 10.1016/j.juro.2008.01.045. Epub 2008 Mar 17.

引用本文的文献

The Impact of Baseline Endogenous Testosterone Levels on Risk Stratification in Pathological Organ-Confined Prostate Cancer: Results in 460 Patients Treated with Robot-Assisted Radical Prostatectomy.基线内源性睾酮水平对病理器官局限性前列腺癌风险分层的影响：460例行机器人辅助根治性前列腺切除术患者的结果

Indian J Surg Oncol. 2025 Apr;16(2):587-594. doi: 10.1007/s13193-024-02109-3. Epub 2024 Oct 12.

From pituitary cells to prostate gland in health and disease: direct and indirect endocrine connections.从垂体细胞到前列腺：健康与疾病状态下的直接和间接内分泌联系

Rev Endocr Metab Disord. 2025 Apr;26(2):187-203. doi: 10.1007/s11154-025-09948-7. Epub 2025 Feb 6.

Elderly Prostate Cancer Patients Treated with Robotic Surgery Are More Likely to Harbor Adverse Pathology Features and Experience Disease Progression: Analysis of the Prognostic Impact of Adverse Pathology Risk Score Patterns Using Briganti's 2012 Nomogram and EAU Risk Groups.接受机器人手术治疗的老年前列腺癌患者更有可能存在不良病理特征并经历疾病进展：使用布里甘蒂2012年列线图和欧洲泌尿外科协会风险组分析不良病理风险评分模式的预后影响

J Clin Med. 2024 Dec 31;14(1):193. doi: 10.3390/jcm14010193.

Advanced age is an independent prognostic factor of disease progression in high-risk prostate cancer: results in 180 patients treated with robot-assisted radical prostatectomy and extended pelvic lymph node dissection in a tertiary referral center.高龄是高危前列腺癌疾病进展的独立预后因素：在三级转诊中心接受机器人辅助根治性前列腺切除术和扩大盆腔淋巴结清扫术的 180 例患者的结果。

Aging Clin Exp Res. 2023 Sep;35(9):1881-1889. doi: 10.1007/s40520-023-02466-z. Epub 2023 Jun 19.

Preoperative endogenous total testosterone predicts prostate cancer progression: results in 580 consecutive patients treated with robot assisted radical prostatectomy for clinically localized disease.术前内源性总睾酮水平可预测前列腺癌进展：580例接受机器人辅助根治性前列腺切除术治疗临床局限性疾病的连续患者的结果

Int Urol Nephrol. 2023 May;55(5):1139-1148. doi: 10.1007/s11255-023-03563-8. Epub 2023 Mar 21.

MRI-Derived Apparent Diffusion Coefficient of Peri-Prostatic Adipose Tissue Is a Potential Determinant of Prostate Cancer Aggressiveness in Preoperative Setting: A Preliminary Report.MRI 衍生的前列腺周围脂肪组织表观扩散系数是术前预测前列腺癌侵袭性的一个潜在决定因素：初步报告。

Int J Environ Res Public Health. 2022 Nov 30;19(23):15996. doi: 10.3390/ijerph192315996.

Endogenous testosterone density as ratio of endogenous testosterone levels on prostate volume predicts tumor upgrading in low-risk prostate cancer.基于前列腺体积的内源性睾酮密度与内源性睾酮水平的比值可预测低危前列腺癌的肿瘤升级。

Int Urol Nephrol. 2021 Dec;53(12):2505-2515. doi: 10.1007/s11255-021-03008-0. Epub 2021 Oct 22.

Endogenous testosterone density predicts unfavorable disease at final pathology in intermediate risk prostate cancer.内源性睾酮密度可预测中危前列腺癌患者最终病理的不良疾病。

Int Urol Nephrol. 2021 Dec;53(12):2517-2526. doi: 10.1007/s11255-021-02990-9. Epub 2021 Sep 27.

Low endogenous testosterone levels are associated with the extend of lymphnodal invasion at radical prostatectomy and extended pelvic lymph node dissection.低内源性睾酮水平与根治性前列腺切除术和广泛盆腔淋巴结清扫术时淋巴结侵犯的程度相关。

Int Urol Nephrol. 2021 Oct;53(10):2027-2039. doi: 10.1007/s11255-021-02938-z. Epub 2021 Jul 6.

本文引用的文献

Biological effect of neoadjuvant androgen-deprivation therapy assessed on specimens from radical prostatectomy: a systematic review.基于根治性前列腺切除术标本评估新辅助雄激素剥夺治疗的生物学效应：一项系统综述

Minerva Urol Nefrol. 2018 Aug;70(4):370-379. doi: 10.23736/S0393-2249.18.03022-9. Epub 2018 Feb 1.

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Serum testosterone and obesity in prostate cancer biology: a call for health promotion in the ageing male.

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