Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Department of Psychiatry, University of Cambridge, Cambridge, UK.
Int J Geriatr Psychiatry. 2020 Oct;35(10):1250-1259. doi: 10.1002/gps.5365. Epub 2020 Jul 2.
We conducted a prospective longitudinal study of plasma cytokines during the Mild Cognitive Impairment (MCI) stage of Lewy body disease and Alzheimer's disease, hypothesizing that cytokine levels would decrease over time and that this would be correlated with decline in cognition.
Older (≥60) people with MCI were recruited from memory services in healthcare trusts in North East England, UK. MCI was diagnosed as due to Alzheimer's disease (MCI-AD) or Lewy body disease (MCI-LB). Baseline and repeat annual clinical and cognitive assessments were undertaken and plasma samples were obtained at the same time. Cytokine assays were performed on all samples using the Meso Scale Discovery V-Plex Plus Proinflammatory Panel 1, which included IFNγ, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13 and TNFα.
Fifty-six patients (21 MCI-AD, 35 MCI-LB) completed prospective evaluations and provided samples up to 3 years after baseline. Six cytokines (IFNγ, IL-1β, IL-2, IL-4, IL-6 and IL-10) showed highly significant (P < .002) decreases over time. AD and LB did not differ in rate of decrease nor were there any effects related to age or general morbidity. Decrease in five of these cytokines (IFNγ, IL-1β, IL-2, IL-4, and IL-10) was highly correlated with decrease in cognition (P < .003).
Peripheral inflammation decreased in both disease groups during MCI suggesting this may be a therapeutic window for future anti-inflammatory agents.
我们进行了一项前瞻性纵向研究，在路易体病和阿尔茨海默病的轻度认知障碍（MCI）阶段研究血浆细胞因子，假设细胞因子水平会随时间降低，且这与认知能力下降相关。
英国东北部医疗保健信托机构的记忆服务部门招募了年龄较大（≥60 岁）的 MCI 患者。MCI 被诊断为由于阿尔茨海默病（MCI-AD）或路易体病（MCI-LB）引起。进行基线和每年重复的临床和认知评估，并在同一时间采集血浆样本。使用 Meso Scale Discovery V-Plex Plus 炎症蛋白 1 进行所有样本的细胞因子检测，该检测包括 IFNγ、IL-1β、IL-2、IL-4、IL-6、IL-8、IL-10、IL-12p70、IL-13 和 TNFα。
56 名患者（21 名 MCI-AD，35 名 MCI-LB）完成了前瞻性评估，并在基线后 3 年内提供了样本。六种细胞因子（IFNγ、IL-1β、IL-2、IL-4、IL-6 和 IL-10）随时间呈显著下降（P<.002）。AD 和 LB 在下降速度上没有差异，也没有与年龄或一般发病情况相关的影响。这五种细胞因子（IFNγ、IL-1β、IL-2、IL-4 和 IL-10）的减少与认知能力下降高度相关（P<.003）。
在 MCI 期间，两种疾病组的外周炎症均减少，这表明这可能是未来抗炎药物的治疗窗口。
