Jun Jin-Sun, Kim Ryul
Department of Neurology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
Department of Neurology, Inha University Hospital, Inha University College of Medicine, Incheon, Korea.
Encephalitis. 2023 Jul;3(3):81-86. doi: 10.47936/encephalitis.2023.00031. Epub 2023 Jun 2.
While the pathomechanisms of α-synucleinopathies are not completely understood, accumulating evidence suggests a role of neuroinflammation in the development and progression of the diseases. In addition, emerging data provide insights into the potential role of central neuroinflammation in prodromal α-synucleinopathies. Given the considerable bidirectional crosstalk between peripheral and central inflammation, peripheral blood inflammatory cytokines may be a useful tool to understand immune responses in association with α-synucleinopathies. Indeed, the accessibility and practicality of using blood samples have facilitated multiple investigations evaluating peripheral blood inflammatory cytokines in overt α-synucleinopathies, whereas the associations between these biomarkers and prodromal α-synucleinopathies remain unclear. In this review, we provide an overview of the current evidence available for the role of peripheral blood inflammatory cytokines in prodromal and overt α-synucleinopathies.
虽然α-突触核蛋白病的发病机制尚未完全明确，但越来越多的证据表明神经炎症在这些疾病的发生和发展中起作用。此外，新出现的数据为中枢神经炎症在前驱性α-突触核蛋白病中的潜在作用提供了见解。鉴于外周炎症和中枢炎症之间存在相当程度的双向交互作用，外周血炎症细胞因子可能是了解与α-突触核蛋白病相关的免疫反应的有用工具。事实上，采集血样的便利性和实用性推动了多项研究，以评估显性α-突触核蛋白病患者外周血炎症细胞因子，而这些生物标志物与前驱性α-突触核蛋白病之间的关联仍不明确。在本综述中，我们概述了目前关于外周血炎症细胞因子在前驱性和显性α-突触核蛋白病中作用的现有证据。
