Goodfield M J, Millard L G
Department of Dermatology, University Hospital, UK.
Postgrad Med J. 1988 Nov;64(757):886-8. doi: 10.1136/pgmj.64.757.886.
Multiple pulmonary malignancy is uncommon and has not been reported in association with systemic sclerosis. We now report such a case in which it is likely that the connective tissue disease occurred as a marker of the internal malignancy. Systemic sclerosis is not generally a reliable indicator of malignant change, but it is possible that in patients who are immunosuppressed, either therapeutically or inherently, the onset of systemic sclerosis should prompt investigation for an underlying cause.
多发性肺恶性肿瘤并不常见，且尚未见与系统性硬化症相关的报道。我们现报告这样一例病例，其中结缔组织病可能是内部恶性肿瘤的标志物。系统性硬化症通常不是恶性病变的可靠指标，但对于接受治疗性免疫抑制或先天性免疫抑制的患者，系统性硬化症的发病可能提示应调查潜在病因。
