Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, 23-3 Shimoaizuki, Matsuoka, Eiheiji, Yoshida, Fukui, 910-1193, Japan.
BMC Ophthalmol. 2020 Jun 19;20(1):244. doi: 10.1186/s12886-020-01518-6.
To determine the effect of various factors to the preservation rate of the conjunctival layer borderlines of glaucomatous eyes treated with anti-glaucoma eye drops.
Anterior segment optical coherence tomography (AS-OCT) images of the bulbar conjunctiva of 328 eyes were analyzed with and without anti-glaucoma eye drops to quantify the preservation rates of the conjunctival layer borderlines.
More anti-glaucoma eye drops and a longer duration of administration were associated with lower preservation rates of the borderlines between both the conjunctival stroma/Tenon's capsule (P < 0.001 and P < 0.001, respectively) and Tenon's capsule/sclera (P < 0.001 and P < 0.001, respectively). Prostaglandin analogs and fixed combinations of β-blockers/prostaglandin analogs were prognostic factors for lower preservation rates of the borderlines between both the conjunctival stroma/Tenon's capsule (P < 0.001 and P = 0.009, respectively) and Tenon's capsule/sclera (P < 0.001 and P = 0.008, respectively).
Numerous anti-glaucoma eye drops and their long-term administration are associated with the disruption of the bulbar conjunctival borderlines detected by AS-OCT.
确定各种因素对使用抗青光眼滴眼液治疗的青光眼眼的结膜层边界保存率的影响。
使用和不使用抗青光眼滴眼液对 328 只眼球的球结膜前段光学相干断层扫描（AS-OCT）图像进行分析，以量化结膜层边界的保存率。
更多的抗青光眼滴眼液和更长的给药时间与结膜基质/ Tenon 囊（P < 0.001 和 P < 0.001）和 Tenon 囊/巩膜（P < 0.001 和 P < 0.001）之间的边界保存率降低有关。前列腺素类似物和β受体阻滞剂/前列腺素类似物的固定组合是结膜基质/ Tenon 囊（P < 0.001 和 P = 0.009）和 Tenon 囊/巩膜（P < 0.001 和 P = 0.008）之间边界保存率降低的预测因素。
大量的抗青光眼滴眼液及其长期应用与 AS-OCT 检测到的球结膜边界破坏有关。
