Division of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Clinical Trial Center, Ewha Womans University Mokdong Hospital, Ewha Womans University, Seoul, Republic of Korea.
Sci Rep. 2020 Jun 19;10(1):9974. doi: 10.1038/s41598-020-66653-y.
There are few studies assessing pre-hypertension and an impaired fasting glucose (IFG) and their combined effects on the cancer risk. We investigated the impact of pre-hypertension on cancer risk and IFG, and their combined effects on the cancer risk. This study included 371,762 subjects (≥40 years) who had never been diagnosed with hypertension, diabetes mellitus (DM), and cancer before. During a mean follow-up of 10.06 ± 1.86 years, 35,605 (9.58%) of the subjects developed cancer. In men only, cancer risk was significantly increased with an increase in the blood pressure (BP) (P for trend < 0.001), and were increased in the hypertension range, but not the pre-hypertension range. When analyzing the combination effect of BP and fasting glucose, cancer risks were serially increased with an increase in the fasting glucose in a dose-dependent manner, but not with an increase in BP. These results were more consistently significant in the never-smoker and non-alcohol drinking groups. However, in women, there was no significant difference. In conclusions, increased BP status or the fasting serum glucose level status were associated with cancer risk in men. Furthermore, the combination of both pre-hypertension and IFG also was associated with a cancer risk in men.
这项研究纳入了 371762 名（年龄≥40 岁）此前从未被诊断患有高血压、糖尿病和癌症的受试者。在平均 10.06±1.86 年的随访期间，35605 名（9.58%）受试者发生了癌症。仅在男性中，随着血压（BP）的升高（趋势 P<0.001），癌症风险显著增加，且在高血压范围内增加，但不在高血压前期范围内增加。当分析 BP 和空腹血糖的联合效应时，癌症风险随着空腹血糖的增加呈剂量依赖性增加，但 BP 的增加则没有。在从不吸烟者和非饮酒者组中，这些结果更为一致显著。然而，在女性中，没有显著差异。总之，BP 状态或空腹血清葡萄糖水平与男性的癌症风险相关。此外，高血压前期和 IFG 的联合也与男性的癌症风险相关。
