University Medical Centre Ljubljana, Clinical Department of Abdominal Surgery, Ljubljana, Slovenia.
University Medical Centre Ljubljana, Clinical Institute of Radiology, Ljubljana, Slovenia.
Radiol Oncol. 2020 Jun 20;54(3):347-352. doi: 10.2478/raon-2020-0038.
Background Electrochemotherapy is an effective treatment of colorectal liver metastases and hepatocellular carcinoma (HCC) during open surgery. The minimally invasive percutaneous approach of electrochemotherapy has already been performed but not on HCC. The aim of this study was to demonstrate the feasibility, safety and effectiveness of electrochemotherapy with percutaneous approach on HCC. Patient and methods The patient had undergone the transarterial chemoembolization and microwave ablation of multifocal HCC in segments III, V and VI. In follow-up a new lesion was identified in segment III, and recognized by multidisciplinary team to be suitable for minimally invasive percutaneous electrochemotherapy. The treatment was performed with long needle electrodes inserted by the aid of image guidance. Results The insertion of electrodes was feasible, and the treatment proved safe and effective, as demonstrated by control magnetic resonance imaging. Conclusions Minimally invasive, image guided percutaneous electrochemotherapy is feasible, safe and effective in treatment of HCC.
背景
电化学疗法是一种有效的治疗结直肠癌肝转移和肝细胞癌（HCC）的方法，可在剖腹手术期间进行。电化学疗法的微创经皮方法已经得到应用，但尚未应用于 HCC。本研究旨在证明经皮电化学疗法治疗 HCC 的可行性、安全性和有效性。
患者和方法
患者曾接受过肝动脉化疗栓塞和微波消融治疗 III、V 和 VI 段的多灶性 HCC。在后续随访中，在 III 段发现了一个新病灶，多学科团队认为该病灶适合微创经皮电化学治疗。治疗采用长针电极，在影像引导下插入。
结果
电极的插入是可行的，治疗结果安全有效，磁共振成像（MRI）检查证实了这一点。
结论
微创、影像引导的经皮电化学治疗 HCC 是可行、安全和有效的。
