Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Rutgers New Jersey Medical School, Newark, New Jersey, USA; Department of Pathology, Immunology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Clin Dermatol. 2020 May-Jun;38(3):354-356. doi: 10.1016/j.clindermatol.2019.07.002. Epub 2019 Jul 11.
Although pityriasis alba is a common dermatologic condition, its pathogenesis is poorly understood, and there are many discrepancies in the literature. To assess the effect of the duration of disease on the histologic findings, a search of cases labeled "pityriasis alba" was performed on any cases submitted to our dermatopathology laboratory. Of 179 cases of pityriasis alba, five cases identified the duration of the disease, when the biopsy was taken. A biopsy for a lesion of only 1-month duration demonstrated groups of large, prominent melanocytes heaped up upon one another. Compared with biopsies from patients who had the lesions for increasingly longer periods of time, it was apparent that the melanocytes became progressively less abundant and smaller with less prominent dendritic processes. The time that the biopsy is taken may affect the histologic findings of pityriasis alba. Additionally, an abundance of melanosomes was observed between the melanocytes in all sections examined which may reflect a problem with the transfer of melanosomes into keratinocytes in this condition.
虽然白色糠疹是一种常见的皮肤病，但它的发病机制尚不清楚，文献中有许多不一致之处。为了评估疾病持续时间对组织学发现的影响，对提交给我们皮肤科病理实验室的任何病例进行了“白色糠疹”标记的病例搜索。在 179 例白色糠疹中，有 5 例确定了疾病的持续时间，以及活检的时间。对仅持续 1 个月的病变进行活检显示，成堆的大而突出的黑素细胞堆积在一起。与病变持续时间越来越长的患者的活检相比，黑素细胞变得越来越稀少，体积越来越小，树突状突起也越来越不明显。活检的时间可能会影响白色糠疹的组织学发现。此外，在所有检查的切片中都观察到黑素细胞之间有大量的黑素小体，这可能反映了在这种情况下黑素小体向角质形成细胞转移存在问题。
