Equine Reproduction Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO.
Equine Reproduction Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO.
J Equine Vet Sci. 2020 Jun;89:103022. doi: 10.1016/j.jevs.2020.103022. Epub 2020 Apr 15.
Numerous similarities in reproductive aging have been documented between the mare and woman. Aging is associated with a decline in fertility. In mares and women, oocyte transfer procedures were initially used to establish that oocyte donor age is associated with oocyte quality. Age-associated differences in oocytes include altered morphology, gene expression, and developmental potential. Reactive oxygen species and mitochondrial dysfunction are thought to be important contributors to loss of oocyte quality. In the woman, aneuploidy is a primary consideration with maternal aging. Although misalignment of chromosomes during meiosis has been observed in the mare, less is known in this area. Reproductive aging will be reviewed in the mare and compared with the woman with emphasis on factors that affect oocyte quality and developmental potential. Areas in which the mare could be used as a research model to study reproductive aging in women will be highlighted.
母马和女性的生殖衰老有许多相似之处。衰老与生育能力下降有关。在母马和女性中，卵母细胞转移程序最初被用于确定卵母细胞供体年龄与卵母细胞质量有关。与年龄相关的卵母细胞差异包括形态改变、基因表达和发育潜能。活性氧和线粒体功能障碍被认为是导致卵母细胞质量下降的重要因素。在女性中，非整倍体是随着母体衰老的一个主要考虑因素。虽然在母马中观察到减数分裂过程中染色体的错位，但在这方面的了解较少。将对母马的生殖衰老进行综述，并与女性进行比较，重点是影响卵母细胞质量和发育潜能的因素。将突出母马可以作为研究女性生殖衰老的研究模型的领域。
