Qiao C, Li D, Zhang Z, Shi C
Department of Oral Pathology, School and Hospital of Stomatology, Jilin University, Changchun, China.
Department of Oral Pathology, School and Hospital of Stomatology, Jilin University, Changchun, China.
Int J Oral Maxillofac Surg. 2020 Dec;49(12):1548-1550. doi: 10.1016/j.ijom.2020.05.012. Epub 2020 Jun 17.
Malignant transformation of basal cell adenoma is extremely rare. We report the case of a 63-year-old Chinese woman, who had noticed a slowing growing mass in her right parotid gland with slight pain for 1 month. Based on physical and ultrasound examinations, a diagnosis of benign salivary gland tumour was made before the surgery. A frozen biopsy was performed, and the diagnosis was basal cell adenoma, with the tumour cells infiltrating the capsule. Routine histopathological examination was performed after the surgery, and a final diagnosis of intracapsular basal cell adenocarcinoma ex basal cell adenoma was made. The patient received a further total parotidectomy and recovered well without any evidence of facial nerve palsy. This case suggests that during frozen biopsy, adequate sectioning including the capsule should be made. With regard to the treatment, we suggest a complete excision of the tumour with tumour-free margins, without any additional auxiliary therapy.
基底细胞腺瘤的恶性转化极为罕见。我们报告一例63岁中国女性病例，她发现右侧腮腺有一生长缓慢的肿块，并伴有轻微疼痛1个月。根据体格检查和超声检查，术前诊断为良性涎腺肿瘤。进行了冰冻活检，诊断为基底细胞腺瘤，肿瘤细胞侵犯包膜。术后进行常规组织病理学检查，最终诊断为基底细胞腺瘤内囊型基底细胞腺癌。患者接受了进一步的全腮腺切除术，恢复良好，无面神经麻痹迹象。该病例提示，在冰冻活检时，应进行包括包膜在内的充分切片。关于治疗，我们建议完整切除肿瘤，切缘无肿瘤残留，无需任何额外的辅助治疗。
