细胞外囊泡：对抗真菌感染的新武器

Extracellular Vesicles: New Bullets to Fight Fungal Infections.

作者信息

Andriantsitohaina Ramaroson, Papon Nicolas

机构信息

SOPAM, U1063, INSERM, UNIV Angers, Angers, France; Federative Structure of Research Cellular Interactions and Therapeutic Applications, SFR 4208 ICAT, Univ Angers, Angers, France.

Federative Structure of Research Cellular Interactions and Therapeutic Applications, SFR 4208 ICAT, Univ Angers, Angers, France; Host-Pathogen Interaction Study Group (GEIHP, EA 3142), UNIV Angers, UNIV Brest, Angers, France.

出版信息

Trends Cell Biol. 2020 Aug;30(8):589-590. doi: 10.1016/j.tcb.2020.05.008. Epub 2020 Jun 18.

DOI:10.1016/j.tcb.2020.05.008

PMID:32563622

Abstract

While behaving as a commensal yeast in healthy people, Candida albicans remains the deadliest fungal pathogen in immunocompromised patients. Halder et al. deciphered unprecedented immunomodulatory properties of monocyte extracellular vesicles in response to Candida infections, paving the way to consider therapeutic innovations for fungal infections but also inflammatory diseases.

摘要

白色念珠菌在健康人群中表现为共生酵母，但在免疫功能低下的患者中仍是最致命的真菌病原体。哈尔德等人破译了单核细胞外囊泡对念珠菌感染做出反应时前所未有的免疫调节特性，为考虑真菌感染以及炎症性疾病的治疗创新铺平了道路。