Department of Surgery, Campus Virchow-Klinikum and Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany; Department Surgery and Transplantation, University Hospital Aachen, Rhine-Westphalia Institute of Technology, Aachen, Germany.
Department of Surgery, Campus Virchow-Klinikum and Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany; Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum and Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Nutrition. 2020 Nov-Dec;79-80:110855. doi: 10.1016/j.nut.2020.110855. Epub 2020 May 15.
Chronic intestinal failure (cIF) is a rare medical condition usually treated by long-term parenteral nutrition (PN). Owing to disease-associated symptoms and treatment-specific complications, patients with cIF commonly present with reduced quality of life (QoL) compared with healthy controls. The aim of this study was to identify factors associated with QoL in patients with cIF.
Ninety adult patients with cIF receiving PN were included in an observational study between 2014 and 2017. QoL based on the novel Short Bowel Syndrome-Quality of Life (SBS-QoL) scale and the Short-Form 36 (SF-36) health survey and nutritional status, liver function, and standard blood chemistry were assessed in every study patient. Univariate and multivariable regressions were conducted to determine independent predictors of QoL.
Oral food intake and plasma citrulline were the two independent variables associated with the SBS-QoL subscale 1 (R = 0.240) and subscale 2 (R = 0.235). Oral intake (β = -43.909, P = 0.015) and citrulline (β = -0.952, P = 0.003) were also significantly associated with the SBS-QoL sum scale (R = 0.209). The results of SF-36 health survey were significantly associated with both SBS-QoL subscale 1 (P <0.001) and subscale 2 (P <0.001) and the SBS-QoL sum scale (P <0.001).
Citrulline and oral intake are predictors of QoL in patients with cIF. Although citrulline appears to be good screening tool, oral food ingestion should be considered as key goal in patients with cIF.
慢性肠道衰竭（cIF）是一种罕见的医学病症，通常通过长期肠外营养（PN）进行治疗。由于疾病相关的症状和治疗特有的并发症，与健康对照组相比，cIF 患者的生活质量（QoL）通常较低。本研究旨在确定与 cIF 患者 QoL 相关的因素。
2014 年至 2017 年间，纳入了 90 名接受 PN 的成年 cIF 患者进行观察性研究。使用新型短肠综合征生活质量（SBS-QoL）量表和健康调查简表 36（SF-36）评估每位研究患者的 QoL 以及营养状况、肝功能和常规血液化学。进行单变量和多变量回归以确定 QoL 的独立预测因子。
口服食物摄入和血浆瓜氨酸是与 SBS-QoL 子量表 1（R=0.240）和子量表 2（R=0.235）相关的两个独立变量。口服摄入（β=-43.909，P=0.015）和瓜氨酸（β=-0.952，P=0.003）也与 SBS-QoL 总和量表显著相关（R=0.209）。SF-36 健康调查结果与 SBS-QoL 子量表 1（P<0.001）、子量表 2（P<0.001）和 SBS-QoL 总和量表（P<0.001）显著相关。
瓜氨酸和口服摄入是 cIF 患者 QoL 的预测因子。尽管瓜氨酸似乎是一种很好的筛选工具，但口服食物摄入应被视为 cIF 患者的关键目标。
