Braun Julia, Arensmeyer Jan Christian, Hausen Annekristin, Stolz Verena, Keller Peter Sebastian, Amarell Nicola, Lurje Georg, Schäfer Nico, Kalff Jörg C, von Websky Martin W
Department of Surgery, University Hospital of Bonn, Bonn, Germany.
Department of Internal Medicine I, University Hospital of Bonn, Bonn, Germany.
Nutr Clin Pract. 2025 Feb;40(1):147-155. doi: 10.1002/ncp.11253. Epub 2024 Dec 12.
Intestinal failure (IF) describes a condition of insufficient absorption capacity and general function of the gastrointestinal tract and may necessitate long-term intravenous fluid and nutrient supplementation. Quality of life (QoL) may be reduced in these patients. The aim of the study was to analyze QoL by two tools (SBS-QoL and SF-12) to elucidate which parameters impact QoL in patients with IF.
QoL was assessed in a cohort of 105 patients with IF at a tertiary referral center for intestinal rehabilitation. Complete data for SBS-QoL and SF-12 were available in 44 of 81 surviving patients at a single time point for a cross-sectional analysis. Medical data, outcome parameters, and comorbidities (Charlson comorbidity index [CCI]) were extracted and entered in a prospective database for analysis and correlation with QoL assessment.
Subscales of SBS-QoL and SF-12 highly correlated with each other (P = -0.64 for physical subscales; P = -0.75 for mental subscales). Significant differences in QoL were detected in patients with Messing Type I (end-jejunostomy) and Type III anatomy (ileocolonic anastomosis) (one-way ANOVA: P < 0.05). Performance of autologous gut reconstruction (AGR) was associated with significantly better physical QoL. CCI correlated significantly with QoL scores. Longer duration of illness resulted in higher QoL in SBS-QoL (reduction of 0.15 per month; P = 0.045).
Both SBS-QoL and SF-12 are useful to determine QoL in patients with IF. AGR was associated with improved QoL by changing SBS-related anatomy and function. Thus, AGR surgery should be included in the treatment plan whenever possible. Comorbidities should be addressed interdisciplinarily to improve QoL.
肠衰竭（IF）是指胃肠道吸收能力和整体功能不足的一种状况，可能需要长期静脉补液和营养补充。这些患者的生活质量（QoL）可能会降低。本研究的目的是通过两种工具（SBS-QoL和SF-12）分析生活质量，以阐明哪些参数会影响IF患者的生活质量。
在一家三级肠道康复转诊中心，对105例IF患者进行了生活质量评估。81例存活患者中有44例在单个时间点获得了完整的SBS-QoL和SF-12数据，用于横断面分析。提取医疗数据、结局参数和合并症（Charlson合并症指数[CCI]），并输入前瞻性数据库，以分析其与生活质量评估的相关性。
SBS-QoL和SF-12的子量表之间高度相关（身体子量表的P值为-0.64；精神子量表的P值为-0.75）。在Messing I型（空肠末端造口术）和III型解剖结构（回结肠吻合术）的患者中检测到生活质量存在显著差异（单因素方差分析：P<0.05）。自体肠道重建（AGR）的实施与身体生活质量显著改善相关。CCI与生活质量评分显著相关。疾病持续时间越长，SBS-QoL的生活质量越高（每月降低0.15；P=0.045）。
SBS-QoL和SF-12都有助于确定IF患者的生活质量。AGR通过改变与SBS相关的解剖结构和功能，与生活质量改善相关。因此，只要有可能，AGR手术应纳入治疗方案。应跨学科处理合并症，以提高生活质量。
