Yasuda Ken, Maki Takakuni, Kinoshita Hisanori, Kaji Seiji, Toyokawa Masaru, Nishigori Ryusei, Kinoshita Yusuke, Ono Yuichi, Kinoshita Ayae, Takahashi Ryosuke
Department of Neurology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8397, Japan.
Department of Neurology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8397, Japan.
Stem Cell Res. 2020 Jul;46:101866. doi: 10.1016/j.scr.2020.101866. Epub 2020 Jun 7.
The susceptibility to neurological and psychiatric disorders reveals sexual dimorphism in the structure and function of human brains. Recent evidence has also demonstrated the sex-related differences in cellular components of the brain, including neurons, microglia, astrocytes, and endothelial cells. Oligodendrocyte precursor cells (OPCs) regulate the neuronal system in various ways and play crucial roles in brain homeostasis beyond their well-known role as a reservoir for mature oligodendrocytes. Although recent studies have shown regional diversities and heterogeneities of OPCs, sex-related differences in OPCs are largely unknown. Here, we revealed transcriptomic differences in OPCs isolated from male and female neonatal rat brains. Furthermore, we demonstrated sex-dependent differences in OPCs regarding proliferation, migration, differentiation, tolerance against ischemic stress, energy metabolism, and the ability to regulate the blood-brain barrier integrity.
对神经和精神疾病的易感性揭示了人类大脑结构和功能中的性别差异。最近的证据还表明，大脑细胞成分存在与性别相关的差异，包括神经元、小胶质细胞、星形胶质细胞和内皮细胞。少突胶质前体细胞（OPC）以多种方式调节神经系统，并且在大脑稳态中发挥关键作用，其作用不仅仅局限于作为成熟少突胶质细胞的储备库这一广为人知的角色。尽管最近的研究已经表明OPC存在区域多样性和异质性，但OPC中与性别相关的差异在很大程度上仍不为人知。在此，我们揭示了从雄性和雌性新生大鼠大脑中分离出的OPC的转录组差异。此外，我们还证明了OPC在增殖、迁移、分化、对缺血应激的耐受性、能量代谢以及调节血脑屏障完整性的能力方面存在性别依赖性差异。
