Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Anatomical Sciences, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
Biomed Pharmacother. 2020 Sep;129:110419. doi: 10.1016/j.biopha.2020.110419. Epub 2020 Jun 18.
Ischemia, being defined as blood supply deficiency is involved in the pathogenesis of a number of life-threatening conditions such as myocardial infarction and cerebral stroke. Assessment of the molecular pathology of these conditions has led to identification of the role of reperfusion in induction and aggravation of tissue injury and necrosis. Thus, the term "ischemia/ reperfusion (I/R) injury" has been introduced. This process involves aberrant regulation of the mitochondrial function, apoptotic and autophagic pathways and signal transducers. More recently, non-coding RNAs including long non-coding RNAs (lncRNAs) ad microRNAs (miRNAs) have been shown to influence I/R injury. Animal studies and clinical investigations have shown up-/down-regulation of tens of lncRNAs and miRNAs in this process. In the current study, we summarize the role of these transcripts in the pathophysiology of I/R injury and their potential as biomarkers for detection of extent of tissue injury.
缺血是指供血不足，与许多危及生命的疾病的发病机制有关，如心肌梗死和中风。对这些疾病的分子病理学的评估导致了再灌注在诱导和加重组织损伤和坏死中的作用的确定。因此，引入了“缺血/再灌注（I/R）损伤”一词。这个过程涉及到线粒体功能、凋亡和自噬途径以及信号转导器的异常调节。最近，非编码 RNA 包括长非编码 RNA（lncRNA）和 microRNA（miRNA）已被证明可以影响 I/R 损伤。动物研究和临床研究表明，在这个过程中，数十种 lncRNA 和 miRNA 的表达水平发生了上调或下调。在本研究中，我们总结了这些转录物在 I/R 损伤病理生理学中的作用及其作为检测组织损伤程度的生物标志物的潜力。
