Jiang Jingyuan, Lin Fengwu, Wu Wenqi, Zhang Zhe, Zhang Chen, Qin Dongliang, Xu Zhenan
Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
Medicine (Baltimore). 2024 Dec 20;103(51):e38492. doi: 10.1097/MD.0000000000038492.
Lung cancer is one of the most threatening malignancies among the different kinds of tumors. The incidence and mortality rate are increasing especially in male. Advances in diagnosis and treatment have been achieve in recent years. However, the lung tumor cells also developing chemo- and radio-resistance. Novel approaches and new treatments are stilled needed to develop for early diagnosis and treatment. Recently, long non-coding RNAs (lncRNAs) original exosomes were proved different expression in lung tumor, which mediate multiple biological processes and is responsible for tumor proliferation and metastasis. In this review, we focus on the emerging roles of both lncRNAs and exosomal lncRNAs in lung cancer and their roles on angiogenesis, metastasis, diagnosis, drug resistance, and immune regulation of lung cancer. Exosome lncRNAs were proved to serve as regulatory factors for gene expression, mediating intercellular communication, and participating in the occurrence and development of various diseases. In addition, exosomes lnc RNA has advantages on the early diagnosis of lung cancer, tumor cell metastasis, drug resistance, and immune regulation. Exosome lncRNAs an provide some unique ideas on how to improve the efficiency of diagnosis and treatment of lung cancer in the future.
肺癌是各类肿瘤中最具威胁性的恶性肿瘤之一。其发病率和死亡率不断上升，尤其是在男性中。近年来，诊断和治疗方面已取得进展。然而，肺肿瘤细胞也在产生化学和放射抗性。仍需要开发新的方法和新的治疗手段用于早期诊断和治疗。最近，源自外泌体的长链非编码RNA（lncRNAs）被证实在肺肿瘤中存在差异表达，其介导多种生物学过程，并与肿瘤增殖和转移有关。在本综述中，我们聚焦于lncRNAs和外泌体lncRNAs在肺癌中的新作用，以及它们在肺癌血管生成、转移、诊断、耐药性和免疫调节方面的作用。外泌体lncRNAs被证明可作为基因表达的调节因子，介导细胞间通讯，并参与各种疾病的发生和发展。此外，外泌体lncRNA在肺癌的早期诊断、肿瘤细胞转移、耐药性和免疫调节方面具有优势。外泌体lncRNAs可为未来如何提高肺癌诊断和治疗效率提供一些独特的思路。
