Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Ear Institute, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Acta Otolaryngol. 2020 Oct;140(10):808-812. doi: 10.1080/00016489.2020.1776385. Epub 2020 Jun 21.
Meniere's disease (MD) is a complex and multifactorial inner ear disease. The etiology of MD is unclear. Significant progress had been made in diagnosis and treatment. Complete cure for this disease is still impossible. This review covers the updated research results in MD in the past decades. Recent publications were critically reviewed. The relationship between Endolymphatic hydrops and Meniere symptoms requires further study. Direct visualization of EH is achieved by special sequences of inner ear MRI. Appearance of EH could be observed in MD patients both in symptomatic and asymptomatic ears. Visualization of EH might make a great substantial improvement in diagnose of MD. The first goal of the management of MD is to reduce the attack frequency. Several safe and effective medical and surgical therapies are practiced to help patients to control vertigo and preserve hearing. There has been no major breakthrough in the pathogenesis research of MD in recent years. Visualization of EH might make a great substantial improvement in diagnose of MD. Clinicians still have few effective ways to alleviate the progress of the disease.
梅尼埃病（MD）是一种复杂的、多因素的内耳疾病。MD 的病因尚不清楚。在诊断和治疗方面已经取得了重大进展。但目前仍无法完全治愈这种疾病。本综述涵盖了过去几十年中 MD 的最新研究结果。对近期出版物进行了批判性评价。内淋巴积水与梅尼埃病症状之间的关系需要进一步研究。内耳 MRI 的特殊序列可直接观察到 EH。EH 可在 MD 患者有症状和无症状的耳朵中观察到。EH 的可视化可能会极大地改善 MD 的诊断。MD 管理的首要目标是减少发作频率。有几种安全有效的药物和手术治疗方法可以帮助患者控制眩晕并保护听力。近年来，MD 的发病机制研究没有重大突破。EH 的可视化可能会极大地改善 MD 的诊断。临床医生仍然很少有有效的方法来减缓疾病的进展。
