Rothman Orthopaedic Institute at Thomas Jefferson University, Philadelphia, PA.
Duke University Medical Center, Department of Orthopaedic Surgery, Durham, NC.
J Arthroplasty. 2020 Sep;35(9):2619-2623. doi: 10.1016/j.arth.2020.04.085. Epub 2020 Apr 30.
Acetabular fractures often require surgical intervention for fracture fixation and can result in premature osteoarthritis of the hip joint. This study hypothesized that total hip arthroplasty (THA) in patients with a prior acetabular fracture who had undergone open reduction and internal fixation (ORIF) is associated with a higher rate of subsequent periprosthetic joint infection (PJI).
About 72 patients with a history of acetabular fracture that required ORIF, undergoing conversion THA between 2000 and 2017 at our institution, were matched based on age, gender, body mass index, Charlson comorbidity index, and date of surgery in a 1:3 ratio with 215 patients receiving primary THA. The mean follow-up for the conversion THA cohort was 2.9 years (range, 1-12.15) and 3.06 years (range, 1-12.96) for the primary THA.
Patients with a previous acetabular fracture, compared with the primary THA patients, had longer operative times, greater operative blood loss, and an increased need for allogeneic blood transfusion (26.4% vs 4.7%). Most notably, PJI rate was significantly higher in acetabular fracture group at 6.9% compared with 0.5% in the control group. Complications, such as aseptic revision, venous thromboembolism, and mortality, were similar between both groups.
The present study demonstrates that conversion THA in patients with prior ORIF of acetabular fractures is associated with higher complication rate, in particular PJI, and less optimal outcome compared with patients undergoing primary THA. The latter findings compel us to seek and implement specific strategies that aim to reduce the risk of subsequent PJI in these patients.
髋臼骨折常需手术干预以固定骨折,可导致髋关节骨关节炎提前发生。本研究假设,对于接受切开复位内固定(ORIF)的髋臼骨折患者,行全髋关节置换术(THA)与更高的假体周围关节感染(PJI)发生率相关。
大约有 72 名髋臼骨折病史患者需要接受 ORIF,他们在本机构于 2000 年至 2017 年之间接受了转换 THA,按照年龄、性别、体重指数、Charlson 合并症指数和手术日期进行 1:3 比例配对,与 215 名接受初次 THA 的患者进行比较。转换 THA 队列的平均随访时间为 2.9 年(范围,1-12.15 年),初次 THA 队列为 3.06 年(范围,1-12.96 年)。
与初次 THA 患者相比,既往有髋臼骨折的患者手术时间更长,术中失血量更大,异体输血需求增加(26.4%比 4.7%)。值得注意的是,髋臼骨折组的 PJI 发生率明显更高,为 6.9%,而对照组为 0.5%。两组并发症(如无菌性翻修、静脉血栓栓塞和死亡率)相似。
本研究表明,与初次 THA 患者相比,对于接受过髋臼骨折切开复位内固定的患者进行转换 THA 与更高的并发症发生率相关,尤其是 PJI,且预后较差。后一种发现迫使我们寻求并实施特定的策略,以降低这些患者发生后续 PJI 的风险。