Ahmadi-Beni Reza, Vand-Rajabpour Fatemeh, Ahmadifard Mohamadreza, Daneshpazhooh Maryam, Noormohammadpour Pedram, Rahmati Javad, Hesari Kambiz Kamyab, Yaseri Mehdi, Tabrizi Mina
Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Indian J Dermatol. 2020 May-Jun;65(3):178-182. doi: 10.4103/ijd.IJD_387_18.
, , and have been implicated in aggressive behavior of squamous cell carcinoma (SCC) and melanoma. However, their expression level in basal cell carcinoma (BCC) has not been elucidated. We hypothesized BCC, contrary to SCC, and melanoma, could be a suitable model to study mechanisms which attenuate tumor metastasis. The aim of this study was to examine the messenger RNA (mRNA) expression levels of , , and in BCC.
Twenty-seven nonmetastatic BCC and twelve normal skin samples were evaluated using real-time reverse transcriptase polymerase chain reaction.
The stemness marker demonstrated marked down-regulation, but and showed no significant change.
Here, we report a negative association between mRNA expression level and nonmetastatic BCC, thus, providing a likely explanation for the fact that normal skin is more reliant on than BCC. BCC may be using decreased mRNA to remain from metastatic potential.
、 和 与鳞状细胞癌（SCC）和黑色素瘤的侵袭性行为有关。然而，它们在基底细胞癌（BCC）中的表达水平尚未阐明。我们假设与SCC和黑色素瘤相反，BCC可能是研究减弱肿瘤转移机制的合适模型。本研究的目的是检测BCC中 、 和 的信使核糖核酸（mRNA）表达水平。
使用实时逆转录聚合酶链反应评估27个非转移性BCC和12个正常皮肤样本。
干性标志物 表现出明显下调，但 和 无显著变化。
在此，我们报告了 mRNA表达水平与非转移性BCC之间的负相关，因此，为正常皮肤比BCC更依赖 这一事实提供了可能的解释。BCC可能通过降低 mRNA水平来保持无转移潜能。
