Bahoush Gholamreza, Vafapour Maryam, Kariminejad Roxana
Associate Professor in Pediatrics, Pediatric Hematologist and Oncologist, Ali-Asghar Children Hospital, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Chief resident of Pediatrics, Ali-Asghar Children Hospital, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Leuk Res Rep. 2020 Jun 8;14:100209. doi: 10.1016/j.lrr.2020.100209. eCollection 2020.
The most common childhood malignancy is acute leukemia. Approximately 15- 20% of it, is Acute myeloid leukemia (AML). The general symptoms of this malignancy include fatigue, weakness, fever, paleness and bleeding disorders. There are two methods of classifying for AML: The French-American-British (FAB) and the World Health Organization (WHO) classification.The M4 eos subtype, also called myelomonocytic leukemia, is one subtype of AML with eosinophilia. The most common cytogenetic variations in this leukemia include inv (16) (p13q22) or the variant t (16; 16) (p13; q22). In this report, we present the first AML-M4 eos case with a new translocation that has not yet been reported.
最常见的儿童恶性肿瘤是急性白血病。其中约15%-20%为急性髓系白血病（AML）。这种恶性肿瘤的一般症状包括疲劳、虚弱、发热、面色苍白和出血性疾病。AML有两种分类方法：法国-美国-英国（FAB）分类法和世界卫生组织（WHO）分类法。M4嗜酸性粒细胞亚型，也称为粒单核细胞白血病，是AML伴嗜酸性粒细胞增多的一种亚型。这种白血病最常见的细胞遗传学变异包括inv(16)(p13q22)或变异型t(16;16)(p13;q22)。在本报告中，我们呈现了首例具有尚未报道的新易位的AML-M4嗜酸性粒细胞病例。
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