Fangshan Hospital, Beijing University of Chinese Medicine, Beijing, China.
Beijing University of Chinese Medicine, Beijing, China.
Integr Cancer Ther. 2020 Jan-Dec;19:1534735420924832. doi: 10.1177/1534735420924832.
Dermatologic toxicities are the most common side effects associated with the targeted drugs epidermal growth factor receptor inhibitors (EGFRIs), in which xerosis commonly complicated by pruritus severely disturbs the quality of life. The study has observed the curative effect of Zizao Yangrong granules (ZYG) from Chishui Xuanzhu in the treatment of EGFRIs-related xerosis and pruritus, as well as evaluating the safety of the prescription. Patients (n = 68) who had xerosis after using EGFRIs were enrolled and then randomly divided into the treatment group and control group, respectively, receiving ZYG and placebo granules combined with vitamin E ointment. The intervention lasted 4 weeks. Changes in xerosis and pruritus were observed, and blood routine examination as well as liver and kidney function . . A total of 66 out of 68 patients finished the study with 34 patients . The effective rates of xerosis among the treatment group and control group were 84.8% and 69.7% after 2 weeks' treatment ( < .05), while they were 84.8% and 75.8% after 4 weeks' treatment ( < .05). The patients in the experimental group had better quality of life than that in the control group ( = .045). ZYG can effectively improve the skin dryness associated with EGFRIs, and significantly improve the quality of life of patients with good safety; however, larger randomized controlled trials are needed to verify these findings.
皮肤毒性是靶向药物表皮生长因子受体抑制剂（EGFRIs）最常见的副作用，其中干燥症常伴有严重瘙痒，严重影响生活质量。本研究观察了赤水玄珠自制药滋燥养荣颗粒（ZYG）治疗 EGFRIs 相关干燥症和瘙痒的疗效，并评价了该处方的安全性。纳入使用 EGFRIs 后出现干燥症的患者（n=68），随机分为治疗组和对照组，分别给予 ZYG 和安慰剂颗粒联合维生素 E 软膏治疗。干预持续 4 周。观察干燥症和瘙痒的变化，以及血常规、肝肾功能。共 68 例患者完成研究，其中治疗组 34 例。治疗 2 周后，治疗组和对照组的干燥症有效率分别为 84.8%和 69.7%（<0.05），治疗 4 周后分别为 84.8%和 75.8%（<0.05）。实验组患者的生活质量优于对照组（=0.045）。ZYG 能有效改善 EGFRIs 相关皮肤干燥，显著提高患者生活质量，且安全性良好；但需要更大规模的随机对照试验来验证这些发现。
