Surgery Unit, Puerto Real University Hospital, Universidad de Cádiz. Cadiz, Spain.
Surgery Unit, Ceuta Hospital, Insalud. Cadiz, Spain.
Cir Cir. 2020;88(4):402-409. doi: 10.24875/CIRU.20001272.
Our main goal is to study the effects on the carbohydrate metabolism. Thus, we designed various experimental surgical models on healthy non-obese Wistar rats to reproduce several conditions. In this sense, we report a new experimental model. It is well known that bariatric surgery has important effects on the control of Type 2 Diabetes Mellitus. The underlying reasons are yet unknown, although the different theories focused in the release of different hormones after the pass of the nutrients through the tract. These released hormones have opposite effects that come together in a balanced glycemic metabolism.
After bariatric surgical techniques, the modified anatomy resulted in an imbalance of the secreted hormones. Wistar rats were randomized in two groups Sham and surgical group. Our model consisted on the transposition of the terminal ileum right after the pylorus. Weight gain, food intake, and basal glycemia were measured weekly.
We did not obtain significant differences between both groups for these functional variables.
This technique involved an early pass of the bolus through the ileum. The change on the luminal pH, along with the lack of enzymes to absorb the content, or the changes in the release of several hormones must be variables to the study. The mortality rate was assumable considering it was an experimental model on animals.
我们的主要目标是研究碳水化合物代谢的影响。因此，我们设计了各种健康非肥胖 Wistar 大鼠的实验性外科模型，以重现多种情况。在这个意义上，我们报告了一种新的实验模型。众所周知，减肥手术对 2 型糖尿病的控制有重要影响。其根本原因尚不清楚，尽管不同的理论集中在营养素通过消化道后释放不同的激素。这些释放的激素具有相反的作用，共同作用于平衡的血糖代谢。
减肥手术后，修改后的解剖结构导致分泌的激素失衡。Wistar 大鼠随机分为假手术组和手术组。我们的模型包括在幽门后直接将末端回肠转位。每周测量体重增加、食物摄入量和基础血糖。
我们没有发现两组之间这些功能变量有显著差异。
该技术涉及食团的早期通过回肠。腔内 pH 值的变化，以及缺乏吸收内容物的酶，或几种激素释放的变化，必须是研究的变量。考虑到这是一个动物实验模型，死亡率是可以假设的。
