Institute of Food and Marine Bio-Resources, College of Biological Science and Engineering, Fuzhou University, Fuzhou, China.
Institute of Biomedical and Pharmaceutical Technology & College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, China.
Crit Rev Food Sci Nutr. 2021;61(13):2225-2236. doi: 10.1080/10408398.2020.1774497. Epub 2020 Jun 22.
Nanoparticles with unique properties have potential applications in food, medicine, pharmacology, and agriculture industries. Accordingly, many significant researches have been conducted to develop novel nanoparticles using chemical and biological techniques. This review focuses on the synthesis of selenium nanoparticles (SeNPs) using polysaccharides as templates. Various instrumental techniques being used to confirm the formation of polysaccharide-SeNPs conjugates and characterize the properties of nanoparticles are also introduced. Finally, the biological activities of the synthesized SeNPs and the influence of structural factors of polysaccharides on the property of synthetic nanocomposites are highlighted. In general, the polysaccharides functionalized SeNPs can be easily obtained using sodium selenite as precursor and ascorbic acid as reductant. The final products having different particle size, morphology, and selenium content exhibit abundant physiological activities. Structural factors of polysacchairdes involving molecular weights, substitution of functional groups, and chain conformation play determinant roles on the properties of nanocomposites, resulting in different biological performances. The review on the achievements and current status of polysaccharides conjugated SeNPs provides insights into this exciting research topic for further studies in the future.
具有独特性质的纳米粒子在食品、医学、药理学和农业等行业具有潜在的应用。因此，人们已经进行了许多重要的研究，以利用化学和生物技术开发新型纳米粒子。本综述重点介绍了使用多糖作为模板合成硒纳米粒子（SeNPs）。还介绍了各种用于确认多糖-SeNPs 缀合物形成和表征纳米粒子性质的仪器技术。最后，强调了合成的 SeNPs 的生物活性以及多糖结构因素对合成纳米复合材料性质的影响。通常，使用亚硒酸钠作为前体和抗坏血酸作为还原剂可以很容易地获得多糖功能化的 SeNPs。具有不同粒径、形态和硒含量的最终产物表现出丰富的生理活性。多糖的结构因素，包括分子量、官能团取代和链构象，对纳米复合材料的性质起着决定性的作用，从而导致不同的生物学性能。对多糖共轭 SeNPs 的研究进展和现状的综述为未来的进一步研究提供了对这一令人兴奋的研究课题的深入了解。
