Verder Henrik, Heiring Christian, Ramanathan Rangasamy, Scoutaris Nikolaos, Verder Povl, Jessen Torben E, Höskuldsson Agnar, Bender Lars, Dahl Marianne, Eschen Christian, Fenger-Grøn Jesper, Reinholdt Jes, Smedegaard Heidi, Schousboe Peter
Department of Pediatrics, Holbaek University Hospital, Holbaek, Denmark.
Department of Neonatology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Acta Paediatr. 2021 Feb;110(2):503-509. doi: 10.1111/apa.15438. Epub 2020 Jul 27.
To develop a fast bedside test for prediction and early targeted intervention of bronchopulmonary dysplasia (BPD) to improve the outcome.
In a multicentre study of preterm infants with gestational age 24-31 weeks, clinical data present at birth were combined with spectral data of gastric aspirate samples taken at birth and analysed using artificial intelligence. The study was designed to develop an algorithm to predict development of BPD. The BPD definition used was the consensus definition of the US National Institutes of Health: Requirement of supplemental oxygen for at least 28 days with subsequent assessment at 36 weeks postmenstrual age.
Twenty-six (43%) of the 61 included infants developed BPD. Spectral data analysis of the gastric aspirates identified the most important wave numbers for classification and surfactant treatment, and birth weight and gestational age were the most important predictive clinical data. By combining these data, the resulting algorithm for early diagnosis of BPD had a sensitivity of 88% and a specificity of 91%.
A point-of-care test to predict subsequent development of BPD at birth has been developed using a new software algorithm allowing early targeted intervention of BPD which could improve the outcome.
开发一种用于预测和早期靶向干预支气管肺发育不良（BPD）的快速床旁检测方法，以改善预后。
在一项针对孕周为24 - 31周的早产儿的多中心研究中，将出生时的临床数据与出生时采集的胃吸出物样本的光谱数据相结合，并使用人工智能进行分析。该研究旨在开发一种算法来预测BPD的发生。所使用的BPD定义是美国国立卫生研究院的共识定义：至少28天需要补充氧气，并在孕龄36周时进行后续评估。
61例纳入研究的婴儿中有26例（43%）发生了BPD。胃吸出物的光谱数据分析确定了用于分类和表面活性剂治疗的最重要波数，出生体重和孕周是最重要的预测临床数据。通过结合这些数据，所得的BPD早期诊断算法的敏感性为88%，特异性为91%。
已使用一种新的软件算法开发出一种床旁检测方法，用于预测出生时BPD的后续发生，从而允许对BPD进行早期靶向干预，这可能会改善预后。
