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流感病毒糖蛋白反应性人源单克隆抗体。

Influenza virus glycoprotein-reactive human monoclonal antibodies.

机构信息

College of Life Sciences, Hebei Agricultural University, Baoding, China.

Research Center of Chinese Jujube, Hebei Agricultural University, Baoding, China.

出版信息

Microbes Infect. 2020 Jul-Aug;22(6-7):263-271. doi: 10.1016/j.micinf.2020.06.003. Epub 2020 Jun 19.

Abstract

Influenza continues to be a significant public health challenge. Two glycoproteins on the surface of influenza virus, hemagglutinin and neuraminidase, play a prominent role in the process of influenza virus infection and release. Monoclonal antibodies targeting glycoproteins can effectively prevent the spread of the virus. In this review, we summarized currently reported human monoclonal antibodies targeting glycoproteins of influenza A and B viruses.

摘要

流感仍然是一个重大的公共卫生挑战。流感病毒表面的两种糖蛋白,血凝素和神经氨酸酶,在流感病毒感染和释放过程中发挥着重要作用。针对糖蛋白的单克隆抗体可以有效地阻止病毒的传播。在这篇综述中,我们总结了目前报道的针对甲型和乙型流感病毒糖蛋白的人源单克隆抗体。

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