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Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro.瑞德西韦和氯喹在体外能有效抑制新出现的新型冠状病毒（2019 - 新冠病毒）。
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First Case of 2019 Novel Coronavirus in the United States.美国首例 2019 新型冠状病毒病例。
N Engl J Med. 2020 Mar 5;382(10):929-936. doi: 10.1056/NEJMoa2001191. Epub 2020 Jan 31.
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Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia.新型冠状病毒感染肺炎在中国武汉的早期传播动力学。
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Importation and Human-to-Human Transmission of a Novel Coronavirus in Vietnam.越南新型冠状病毒的输入及人传人情况
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.中国武汉地区 2019 年新型冠状病毒感染患者的临床特征。
Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
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A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster.一个涉及 2019 年新型冠状病毒的家庭聚集性肺炎病例，提示存在人际传播：一项家庭聚集性研究。
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Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV.比较瑞德西韦与洛匹那韦利托那韦和干扰素β联合治疗中东呼吸综合征冠状病毒的疗效。
Nat Commun. 2020 Jan 10;11(1):222. doi: 10.1038/s41467-019-13940-6.
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Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase.广谱抗病毒药物瑞德西韦通过高度分化的 RNA 依赖的 RNA 聚合酶抑制人类地方性和人畜共患的德尔塔冠状病毒。
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Human Coronavirus in Hospitalized Children With Respiratory Tract Infections: A 9-Year Population-Based Study From Norway.人冠状病毒在呼吸道感染住院患儿中的研究：来自挪威的一项 9 年的基于人群的研究。
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Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin.由源自蝙蝠的 HKU2 相关冠状病毒引起的致命猪急性腹泻综合征。
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持续的 SARS-CoV-2 疫情威胁及其对未来全球公共卫生的影响。

The continued epidemic threat of SARS-CoV-2 and implications for the future of global public health.

机构信息

University of North Carolina at Chapel Hill, Gillings School of Global Public Health, Chapel Hill, NC, United States.

Department of Microbiology and Immunology, The University of Maryland School of Medicine, Baltimore, MD, United States.

出版信息

Curr Opin Virol. 2020 Feb;40:37-40. doi: 10.1016/j.coviro.2020.05.010. Epub 2020 Jun 4.

DOI:10.1016/j.coviro.2020.05.010
PMID:32569751
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7269927/
Abstract

A new coronavirus (CoV) called SARS-CoV-2 emerged in Wuhan, China in December 2019 as the etiological agent of a viral pneumonia called COVID-19. The global spread of SARS-CoV-2 has been so extensive that the WHO declared COVID-19 a pandemic on March 11, 2020. Below, we discuss the emergence of SARS-CoV-2 and provide the historical context, which strongly suggests emerging CoVs provide an immediate threat to global public health and will continue to do so in the future.

摘要

一种新型冠状病毒（CoV）于 2019 年 12 月在中国武汉出现，是一种名为 COVID-19 的病毒性肺炎的病原体。SARS-CoV-2 在全球范围内广泛传播，世界卫生组织于 2020 年 3 月 11 日宣布 COVID-19 为大流行。下面，我们讨论 SARS-CoV-2 的出现，并提供历史背景，这强烈表明新兴的 CoV 对全球公共卫生构成了直接威胁，并将在未来继续如此。