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人体原位肝移植过程中血浆胆碱酯酶活性的变化

Changes of plasma cholinesterase activity during orthotopic liver transplantation in man.

作者信息

Aldrete J A, O'Higgins J W, Holmes J

出版信息

Transplantation. 1977 May;23(5):404-6. doi: 10.1097/00007890-197705000-00004.

DOI:10.1097/00007890-197705000-00004
PMID:325708
Abstract

Variations of plasma cholinesterase activity were studied in eight patients with end stage liver disease having orthotopic liver transplantation and five other patients with hepatic cirrhosis undergoing surgical procedures. Serum cholinesterase activity was found to be below normal limits in every patient, even more so in those having hepatic homotransplantation, probably because of the greater severity of their disease. Blood transfusions increased pseudocholinesterase activity to normal or nearly normal levels; but only after successful transplantation did these levels remain within normality, thus suggesting that the homografts promptly assume production of the serum enzyme.

摘要

对8例接受原位肝移植的终末期肝病患者和另外5例接受外科手术的肝硬化患者的血浆胆碱酯酶活性变化进行了研究。发现每名患者的血清胆碱酯酶活性均低于正常范围,在接受肝脏同种移植的患者中更是如此,这可能是因为他们的病情更为严重。输血使假性胆碱酯酶活性升高至正常或接近正常水平;但只有在移植成功后这些水平才保持在正常范围内,这表明同种移植器官迅速承担起了血清酶的产生功能。

相似文献

1
Changes of plasma cholinesterase activity during orthotopic liver transplantation in man.人体原位肝移植过程中血浆胆碱酯酶活性的变化
Transplantation. 1977 May;23(5):404-6. doi: 10.1097/00007890-197705000-00004.
2
Atypical serum cholinesterase eliminated by orthotopic liver transplantation.原位肝移植消除非典型血清胆碱酯酶。
Anesthesiology. 1987 Aug;67(2):273-4. doi: 10.1097/00000542-198708000-00025.
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An assessment of the value of serum cholinesterase as a liver function test and in the diagnosis of jaundice.血清胆碱酯酶作为肝功能检测指标及在黄疸诊断中的价值评估。
Gut. 1960 Dec;1(4):294-302. doi: 10.1136/gut.1.4.294.
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[Pseudocholinesterase in patients with and without liver diseases (author's transl)].[患肝病和未患肝病患者的假性胆碱酯酶(作者译)]
Med Klin. 1978 Oct 13;73(41):1422-6.
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Atypical serum cholinesterase eliminated by orthotopic liver transplantation.原位肝移植消除非典型血清胆碱酯酶。
Anesthesiology. 1988 Mar;68(3):474. doi: 10.1097/00000542-198803000-00038.
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[Diagnostic significance of cholinesterase determination in human serum (author's transl)].人血清胆碱酯酶测定的诊断意义(作者译)
MMW Munch Med Wochenschr. 1979 Nov 16;121(46):1527-3.
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Serum levels of C3 and cholinesterase in various diseases of the liver.肝脏各种疾病中血清C3和胆碱酯酶水平。
Acta Hepatogastroenterol (Stuttg). 1976 Feb;23(1):19-25.
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Postoperative serum cholinesterase activity following successful renal transplantation.
Br J Anaesth. 1979 Sep;51(9):881-4. doi: 10.1093/bja/51.9.881.
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The value of plasma cholinesterase in children with severe liver disease.血浆胆碱酯酶在重症肝病患儿中的价值。
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Dual significance of hepatic cholinesterase as an index of liver involvement and state of protein-calorie malnutrition.肝胆碱酯酶作为肝脏受累指标及蛋白质-热量营养不良状态的双重意义。
Gaz Egypt Paediatr Assoc. 1975 Apr;23(2):133-8.

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Hereditary pseudocholinesterase deficiency in a 4-year-old girl: a case report.一名4岁女童的遗传性假性胆碱酯酶缺乏症:病例报告
J Med Case Rep. 2025 Mar 28;19(1):145. doi: 10.1186/s13256-025-05183-5.