Gentz H D, Schlicht I, Wiederholt W
Med Klin. 1978 Oct 13;73(41):1422-6.
The activity of plasma pseudocholinesterase (PChE) was determined on admission and prior to discharge from the hospital in 200 patients admitted consecutively to a medical ward specialized in liver and infectious diseases. In 24% of patients without liver diseases and without malignant growths the pseudocholinesterase-activity was below normal on admission but increased during the observation period toward normal values. There was a negative correlation between pseudocholinesterase-activity and the intensity of the inflammatory activity as measured by granulocyte count, ESR, body temperature and IgA. This correlation could be established for patients without demonstrable liver pathology as well as for liver diseases. Elevated pseudocholinesterase-levels were observed only in three cases of toxic liver injury (2 heavy drinkers, 1 case of polytoxicomania). In all patients with malignant diseases subnormal values of pseudocholinesterase were observed. Only one patient had normal pseudocholinesterase-activity on admission, but the pseudocholinesterase decreased within a few weeks to subnormal values as the underlying malignant melanoma progressed. The decrease of pseudocholinesterase-activity in malignant diseases was independent of the presence of liver metastases.
对连续入住一家肝脏和传染病专科内科病房的200例患者，在入院时及出院前测定了血浆假性胆碱酯酶（PChE）活性。在无肝脏疾病且无恶性肿瘤的患者中，24%在入院时假性胆碱酯酶活性低于正常，但在观察期内升高至正常水平。假性胆碱酯酶活性与通过粒细胞计数、血沉、体温和IgA测量的炎症活动强度之间存在负相关。这种相关性在无明显肝脏病变的患者以及肝脏疾病患者中均能确立。仅在3例中毒性肝损伤患者中观察到假性胆碱酯酶水平升高（2例重度饮酒者，1例多药滥用者）。在所有恶性疾病患者中均观察到假性胆碱酯酶值低于正常。仅1例患者入院时假性胆碱酯酶活性正常，但随着潜在的恶性黑色素瘤进展，几周内假性胆碱酯酶降至低于正常水平。恶性疾病中假性胆碱酯酶活性的降低与肝转移的存在无关。
