Department of Medicinal and Life Science, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan.
National Institute of Advanced Industrial Science and Technology, 2-4-7 Aomi, Koto-ku, Tokyo, 135-0064, Japan.
J Antibiot (Tokyo). 2020 Nov;73(11):790-793. doi: 10.1038/s41429-020-0339-9. Epub 2020 Jun 22.
A new curromycin-related compound, neocurromycin A (2), was isolated from the fermented broth of Streptomyces sp. RAI364. The molecular formula of 2 was established as CHNO by ESI-MS and the structure was elucidated by NMR spectroscopic analyses. Neocurromycin A showed selective cytotoxicity against MKN45 human gastric cancer cells in a nutrient-deprived medium with an IC of 380 nM and inhibited the expression of the molecular chaperone GRP78 in HT1080 G-L cells in the presence of 10 mM of 2-deoxyglucose with an IC of 1.7 µM.
一种新的卷曲霉素相关化合物，新卷曲霉素 A（2），从链霉菌 RAI364 的发酵液中分离得到。2 的分子式通过 ESI-MS 确定为 CHNO，结构通过 NMR 光谱分析阐明。新卷曲霉素 A 在营养缺乏的培养基中对 MKN45 人胃癌细胞表现出选择性细胞毒性，IC 为 380 nM，并在存在 10 mM 2-脱氧葡萄糖的情况下抑制 HT1080 G-L 细胞中分子伴侣 GRP78 的表达，IC 为 1.7 μM。
