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Curromycin A as a GRP78 downregulator and a new cyclic dipeptide from Streptomyces sp.

作者信息

Hayakawa Yoichi, Akimoto Minami, Ishikawa Akari, Izawa Masumi, Shin-ya Kazuo

机构信息

Department of Medicinal and Life Science, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.

Biological Information Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 2016 Mar;69(3):187-8. doi: 10.1038/ja.2015.115. Epub 2015 Nov 25.

DOI:10.1038/ja.2015.115
PMID:26601685
Abstract
摘要

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Effect on tumor cells of blocking survival response to glucose deprivation.阻断对葡萄糖剥夺的存活反应对肿瘤细胞的影响。
J Natl Cancer Inst. 2004 Sep 1;96(17):1300-10. doi: 10.1093/jnci/djh243.
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Remarkable tolerance of tumor cells to nutrient deprivation: possible new biochemical target for cancer therapy.肿瘤细胞对营养剥夺的显著耐受性:癌症治疗可能的新生化靶点。
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Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions.葡萄糖调节应激基因GRP78在人恶性而非良性乳腺病变中过表达。
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Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors.负责哺乳动物葡萄糖调节蛋白转录诱导的顺式作用内质网应激反应元件的鉴定。碱性亮氨酸拉链转录因子的参与。
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Structure of a new antibiotic curromycin A produced by a genetically modified strain of Streptomyces hygroscopicus, a polyether antibiotic producing organism.
J Antibiot (Tokyo). 1985 May;38(5):669-73. doi: 10.7164/antibiotics.38.669.
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An Hsp70-like protein in the ER: identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein.内质网中一种热休克蛋白70样蛋白:与78kd葡萄糖调节蛋白及免疫球蛋白重链结合蛋白的一致性。
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16S ribosomal DNA amplification for phylogenetic study.用于系统发育研究的16S核糖体DNA扩增。
J Bacteriol. 1991 Jan;173(2):697-703. doi: 10.1128/jb.173.2.697-703.1991.
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New triene-beta-lactone antibiotics, triedimycins A and B.
J Antibiot (Tokyo). 1991 Apr;44(4):453-5. doi: 10.7164/antibiotics.44.453.