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当前和未来治疗 COVID-19 的方法。

Current and future therapeutical approaches for COVID-19.

机构信息

Henan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou University, Zhengzhou 450001, China.

School of Pharmaceutical Science, Zhengzhou University, Zhengzhou, Henan 450001, China.

出版信息

Drug Discov Today. 2020 Aug;25(8):1545-1552. doi: 10.1016/j.drudis.2020.06.018. Epub 2020 Jun 20.

DOI:10.1016/j.drudis.2020.06.018
PMID:32574697
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7305909/
Abstract

We review the evolution of our clinical understanding of COVID-19, possible therapeutic targets, and prospects for COVID-19 management.

摘要

我们回顾了对 COVID-19 的临床认识的演变、可能的治疗靶点以及 COVID-19 管理的前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4fc/7305909/d3e2a5c1b862/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4fc/7305909/d3e2a5c1b862/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4fc/7305909/d3e2a5c1b862/gr1_lrg.jpg

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J Cell Physiol. 2020 Dec;235(12):9133-9142. doi: 10.1002/jcp.29785. Epub 2020 May 11.
2
Editorial: Nicotine and SARS-CoV-2: COVID-19 may be a disease of the nicotinic cholinergic system.社论:尼古丁与严重急性呼吸综合征冠状病毒2:2019冠状病毒病可能是一种烟碱能胆碱能系统疾病。
Toxicol Rep. 2020 Apr 30;7:658-663. doi: 10.1016/j.toxrep.2020.04.012. eCollection 2020.
3
Ongoing Clinical Trials for the Management of the COVID-19 Pandemic.正在进行的 COVID-19 大流行管理临床试验。
具有抗SARS-CoV-2活性的天然产物及其衍生物的药理相关性与化学合成进展
ChemistrySelect. 2021 Nov 15;6(42):11502-11527. doi: 10.1002/slct.202103301. Epub 2021 Nov 8.
4
Functionalized Dendrimer Platforms as a New Forefront Arsenal Targeting SARS-CoV-2: An Opportunity.功能化树枝状大分子平台作为靶向新型冠状病毒的前沿新武器库:一次机遇。
Pharmaceutics. 2021 Sep 18;13(9):1513. doi: 10.3390/pharmaceutics13091513.
5
Angiotensin-Converting Enzyme 2 in the Pathogenesis of Renal Abnormalities Observed in COVID-19 Patients.血管紧张素转换酶2在新冠病毒病患者肾脏异常发病机制中的作用
Front Physiol. 2021 Aug 23;12:700220. doi: 10.3389/fphys.2021.700220. eCollection 2021.
6
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Rev Lat Am Enfermagem. 2021 Aug 30;29:e3474. doi: 10.1590/1518-8345.4975.3474. eCollection 2021.
7
The race to treat COVID-19: Potential therapeutic agents for the prevention and treatment of SARS-CoV-2.治疗 COVID-19 的竞赛:预防和治疗 SARS-CoV-2 的潜在治疗药物。
Eur J Med Chem. 2021 Mar 5;213:113157. doi: 10.1016/j.ejmech.2021.113157. Epub 2021 Jan 12.
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Eur J Med Chem. 2021 Jan 1;209:112905. doi: 10.1016/j.ejmech.2020.112905. Epub 2020 Oct 11.
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Toxicol Rep. 2020;7:1366-1372. doi: 10.1016/j.toxrep.2020.10.002. Epub 2020 Oct 8.
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