Malangoni M A, Evers B M, Peyton J C, Wellhausen S R
Department of Surgery, University of Louisville School of Medicine, Kentucky 40292.
Am J Surg. 1988 Feb;155(2):298-302. doi: 10.1016/s0002-9610(88)80720-7.
Although the preservation of splenic tissue may prevent overwhelming infection after splenectomy, the degree of protection conferred by small remnants has not been optimal. We investigated whether either splenic reticuloendothelial clearance of a blood flow-dependent colloid or macrophage and T-cell populations might be altered by resection or autotransplantation of the spleen. Our results have shown that bloodstream reticuloendothelial clearance of technetium 99m sulfur colloid is not impaired by splenectomy, partial resection of the spleen, or splenic autotransplantation. Such clearance is dependent on spleen weight and is not related to differences in either macrophage or helper or suppressor T-cell populations. This suggests that autotransplantation of the spleen is inferior to preservation of even a small hilar remnant and implies that repair or partial resection of the spleen will provide greater protection than autotransplantation.
尽管保留脾脏组织可预防脾切除术后的暴发性感染，但小的脾脏残余组织所提供的保护程度并不理想。我们研究了脾切除术、脾脏部分切除术或自体移植术是否会改变脾脏对血流依赖性胶体的网状内皮清除功能，以及巨噬细胞和T细胞群体。我们的结果表明，脾切除术、脾脏部分切除术或脾脏自体移植术均不会损害血流中99m锝硫胶体的网状内皮清除功能。这种清除功能取决于脾脏重量，与巨噬细胞、辅助性T细胞或抑制性T细胞群体的差异无关。这表明脾脏自体移植术不如保留哪怕一小部分脾门残余组织，意味着修复或部分切除脾脏比自体移植能提供更大的保护。
