Department of Obstetrics and Gynecology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
J Obstet Gynaecol Res. 2020 Sep;46(9):1827-1834. doi: 10.1111/jog.14353. Epub 2020 Jun 23.
To investigate the expression and function of actin gamma 1 (ACTG1) in ovarian cancer.
We performed immunohistochemical staining of 176 ovarian cancer tissue samples in a human tissue microarray to detect expression of ACTG1. Staining intensity was examined in relation to clinicopathological parameters. To investigate the prognostic value of ACTG1, ACTG1 mRNA data from 300 ovarian cancer patients in The Cancer Genome Atlas database were examined.
The immunohistochemical results demonstrated that levels of ACTG1 were reduced in the samples of human ovarian cancer tissue that were examined, and the levels negatively correlated with various clinicopathological parameters. Levels of ACTG1 mRNA also negatively correlated with clinical stage. In Kaplan-Meier survival analysis, higher levels of ACTG1 mRNA were associated with improved overall survival. In multivariate analysis by Cox regression, ACTG1 expression was identified as an independent prognostic marker of favorable overall survival.
ACTG1 may represent a valuable marker for the prognosis of ovarian cancer, and further studies of ACTG1 are warranted.
研究肌动蛋白γ 1（ACTG1）在卵巢癌中的表达和功能。
我们在人类组织微阵列中对 176 个卵巢癌组织样本进行了免疫组织化学染色，以检测 ACTG1 的表达。检查染色强度与临床病理参数的关系。为了研究 ACTG1 的预后价值，我们检查了来自癌症基因组图谱数据库的 300 名卵巢癌患者的 ACTG1mRNA 数据。
免疫组织化学结果表明，所检查的人卵巢癌组织样本中 ACTG1 水平降低，并且水平与各种临床病理参数呈负相关。ACTG1mRNA 水平也与临床分期呈负相关。在 Kaplan-Meier 生存分析中，较高水平的 ACTG1mRNA 与总体生存率提高相关。通过 Cox 回归的多变量分析，ACTG1 表达被确定为总体生存率良好的独立预后标志物。
ACTG1 可能是卵巢癌预后的一个有价值的标志物，需要进一步研究 ACTG1。
