Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Thorac Cancer. 2020 Aug;11(8):2343-2346. doi: 10.1111/1759-7714.13530. Epub 2020 Jun 24.
A 70-year-old male was referred to our hospital with lower limb muscle weakness and numbness of the left hand. The patient had previously been diagnosed seven years ago with lung cancer accompanied by central airway obstruction and had received chemoradiotherapy following placement of a metallic stent. Computed tomography (CT) scan revealed an osteolytic lesion which was adjacent to the fractured stent. T2-weighted magnetic resonance imaging (MRI) demonstrated high signal intensity in the disc space. The patient was diagnosed with spondylodiscitis and spinal epidural abscess related to the airway stent. Despite hemilaminectomy, laminectomy and long-term antibiotic therapy, the infection was uncontrolled. Moreover, osteolytic destruction and kyphotic deformity progressed. Removal of the airway stent was necessary; however, it was impossible because bronchial resection was required and the risk of mediastinal injury was considered to be high. The patient subsequently received palliative care. Long-term airway stenting can cause spondylodiscitis and spinal epidural abscess. Indications for the placement of metallic stents for malignant central airway obstruction should be carefully evaluated after considering the difficulty in removal and the long-term risk of severe complications. KEY POINTS: Significant findings of the study Long-term placement and fracture of the airway stent can cause spondylodiscitis and spinal epidural abscess. What this study adds The indication of placement of a metallic stent for malignant central airway obstruction should be considered with caution, especially if long-term survival can be expected.
一位 70 岁男性因下肢肌无力和左手麻木被转诊至我院。该患者七年前曾被诊断为肺癌,伴有中央气道阻塞,并在放置金属支架后接受了放化疗。计算机断层扫描(CT)显示溶骨性病变,与骨折的支架相邻。T2 加权磁共振成像(MRI)显示椎间盘空间高信号强度。患者被诊断为与气道支架相关的脊椎炎和脊髓硬膜外脓肿。尽管进行了半椎板切除术、椎板切除术和长期抗生素治疗,但感染仍未得到控制。此外,溶骨性破坏和后凸畸形进展。需要取出气道支架;但是,由于需要进行支气管切除术,并且考虑到纵隔损伤的风险很高,因此无法进行。患者随后接受了姑息治疗。长期气道支架置入可引起脊椎炎和脊髓硬膜外脓肿。在考虑到取出困难和严重并发症的长期风险后,应仔细评估恶性中央气道阻塞金属支架置入的适应证。
研究的重要发现
气道支架的长期放置和骨折可导致脊椎炎和脊髓硬膜外脓肿。
本研究增加的内容
对于恶性中央气道阻塞放置金属支架的适应证应谨慎考虑,尤其是如果预期长期生存的话。