犬繁育群体中的自发性家族性系统性红斑狼疮
Spontaneous familial systemic lupus erythematosus in a canine breeding colony.
作者信息
Hubert B, Teichner M, Fournel C, Monier J C
机构信息
Ecole Nationale Vétérinaire de Lyon, Marcy L'Etoile, France.
出版信息
J Comp Pathol. 1988 Jan;98(1):81-9. doi: 10.1016/0021-9975(88)90032-1.
PMID:3257973
Abstract
A colony of German shepherd dogs was studied in which a high proportion of antinuclear antibody (ANAb) carriers and dogs with systemic lupus erythematosus (SLE)-like signs were found. The titre of serum thymulin and the percentage of circulating T lymphocytes were both low. The incidence of disease decreased down the generations through the introduction of outside sires, thus suggesting a genetic origin for the disease.
摘要
对一群德国牧羊犬进行了研究，发现其中有高比例的抗核抗体（ANAb）携带者以及出现系统性红斑狼疮（SLE）样症状的犬只。血清胸腺素水平和循环T淋巴细胞百分比均较低。通过引入外来种公犬，疾病的发生率在几代中逐渐降低，因此提示该疾病有遗传起源。
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