Molecular therapeutic targets in non-small cell lung cancer.

INTRODUCTION

Several targetable genetic alterations have been identified in non-small cell lung cancers (NSCLC) and drugs targeting these alterations have been approved for the management of advanced NSCLC patients. Driver mutations with emerging clinical trial data include exon 20 insertion mutations, amplification, point mutations, rearrangements, amplification and mutations, and amplification and translocations.

AREAS COVERED

We reviewed English-language articles indexed in Medline and PubMed up to the 1 of June 2020. In addition, the proceedings of major conferences were reviewed for relevant abstracts. We report data published regarding targeted therapies which are currently approved and for those which are emerging in advanced or metastatic NSCLC.

EXPERT REVIEW

While these drugs have been shown to be efficacious and tolerable, resistance almost always develops. Though next-generation tyrosine kinase inhibitors (TKIs) have been developed, the appropriate sequencing of these drugs is not clear. Evaluating combination therapies to prevent or delay the onset of resistance and understanding mechanisms of resistance are critical areas of emerging research.