Conte R, Giovanardi L, Tazzari P L, De Rosa V, Rodorigo G, Re M C
Servizio di Immunoematologia e Trasfusionale, Università, Policlinico S. Orsola, Bologna, Italia.
Vox Sang. 1988;54(1):47-51. doi: 10.1111/j.1423-0410.1988.tb01612.x.
We tested serum samples from 11 HIV-seropositive and 32 HIV-seronegative Italian patients with hemophilia A or B for the presence of lymphocytotoxic antibodies (LCTAs). No patients had the acquired immune deficiency syndrome and all had received over many years heat-untreated commercial clotting factors. LCTAs directed mainly to B cells, were significantly present in 5/6 HIV-seropositive patients with hemophilia A and in 5/5 HIV-seropositive patients with hemophilia B. The presence of LCTAs in HIV-seronegative hemophiliacs was significantly correlated with both a decrease of T cells and an increase in serum levels of IgG and IgM.
我们检测了11名意大利血友病A或B患者的血清样本，这些患者HIV血清反应呈阳性，另外检测了32名HIV血清反应呈阴性的意大利血友病患者的血清样本，以检测淋巴细胞毒性抗体（LCTA）的存在情况。所有患者均未患获得性免疫缺陷综合征，且多年来均接受未经热处理的商业凝血因子治疗。主要针对B细胞的LCTA在5/6名HIV血清反应呈阳性的血友病A患者以及5/5名HIV血清反应呈阳性的血友病B患者中显著存在。HIV血清反应呈阴性的血友病患者中LCTA的存在与T细胞减少以及血清IgG和IgM水平升高均显著相关。
