Fabio G, Smeraldi R S, Gringeri A, Marchini M, Bonara P, Mannucci P M
Institute of Internal Medicine, Infectious Diseases and Immunopathology, University of Milan, Italy.
Br J Haematol. 1990 Aug;75(4):531-6. doi: 10.1111/j.1365-2141.1990.tb07794.x.
We compared the frequencies of HLA antigens in two matched groups of 31 HIV-seronegative and 31 HIV-seropositive haemophiliacs, exposed during the years 1981-85 to comparable amounts and batches of presumably infectious clotting factor concentrates. The frequency of A2 was significantly higher in HIV-seropositive than in seronegative haemophiliacs, with a relative risk (RR) of seroconversion of 3.92, whereas both Bw52 and DR4 were negatively associated with it. We also studied the distribution of HLA antigens in a larger group of 76 HIV-seropositive haemophiliacs, who were at different clinical stages of HIV infection (CDC classes II-IV) but were comparable for age and time elapsed since seroconversion. DR3 and DQw2 antigens were, particularly when concomitantly present, associated with a high risk of developing symptomatic HIV infection (RR = 11.79 and 25.33). Our data suggest that the HLA region controls susceptibility to infection with HIV and its progression to symptomatic disease in Italian haemophiliacs.
我们比较了两组匹配的血友病患者的HLA抗原频率，一组31名HIV血清阴性患者，另一组31名HIV血清阳性患者，他们在1981年至1985年期间接触了数量相当且批次相同的可能具有传染性的凝血因子浓缩物。HIV血清阳性血友病患者中A2的频率显著高于血清阴性血友病患者，血清转化的相对风险（RR）为3.92，而Bw52和DR4与之呈负相关。我们还研究了76名HIV血清阳性血友病患者中HLA抗原的分布情况，这些患者处于HIV感染的不同临床阶段（美国疾病控制与预防中心II - IV级），但在年龄和血清转化后的时间方面具有可比性。DR3和DQw2抗原，尤其是当它们同时出现时，与出现有症状HIV感染的高风险相关（RR分别为11.79和25.33）。我们的数据表明，在意大利血友病患者中，HLA区域控制着对HIV感染的易感性及其发展为有症状疾病的进程。
